Objective There is a relative lack of information about infections occurring in children following allogeneic hematopoietic stem cell transplants (allo‐HSCT) in developing countries. Herein, we describe the incidence rates of different infections according to the transplant period and baseline condition in Colombia. Methods In a retrospective cohort study of all children who underwent allo‐HSCTs from 2012 to 2017 in a hospital in Cali, Colombia, we reviewed medical records from the first post‐transplant day until day + 365 to describe microbiologically confirmed incidence rates of infections and deaths during three post‐transplant periods and according to baseline condition. Results Most allo‐HSCT (n = 144, 96%) were followed by infections over the following year, mostly due to bacteria and cytomegalovirus (4.3 and 3.3 per 1000 patient‐days, respectively). Children were at the highest risk for infection in the first 30 days post‐HSTC, but mortality was highest after 100 days. Overall, high mortality (n = 44, 31.7%) was associated with infections, especially from extensively drug‐resistant bacteria, adenovirus, and aspergillosis. Infection rates were similar independent of the baseline condition. Conclusion Almost all children in this cohort developed infections post allo‐HSCT. Describing the distribution of infections throughout the first post allo‐HSCT year allows clinicians to narrow the differential diagnosis of infections according to the post‐transplant period. This is especially useful when prioritizing interventions in children receiving HSCT in stringent healthcare systems in developing countries.

BackgroundSystemic lupus erythematosus (SLE) is an autoimmune disease characterised by multiple organ involvement, lupus nephritis (LN)1 being one of the most serious manifestationsObjectivesTo establish associated factors with lupus nephritis development in patients with SLEMethodsCross-sectional study taken from a cohort of 1175 patient with SLE who met criteria for classification for ACR 1997 or ,SLICC 2012 between 2007 and 2015. Bivariate analysis of multiple characteristics was performed between patients with presence and absence of LN at through chi squared and U Mann Whitney. Multivariate analysis was performed by logistic regression to adjust for significant associationsResultsThe cohort of patients with SLE 90% was female gender, had an average of 44 years with a duration of the disease of 10.6 years. Joint and haematological involvement was present in more than 80% of patients. The presence of antibodies against DNA and low complement was found in 53% and 60% respectively. The exposure to dyes was 44% and tobacco 21%.It was found 455 patients with SLE and LN with an average age of 41 years and a time of evolution of SLE of 11 years. The male gender proportion was higher in those who presented LN with 11.6% compared to 7.1% who did not have LN. The immunological profile of patients with NL was characterised by a higher proportion of positivity for Anti-DNA, anti-SM and low complement. Male gender has a greater association with LN (OR 1.98 CI 95% 1,20–3,27). Having a disease duration greater than 10 years increases the association with LN (OR 1.48 95% CI 1–2,16) as well as the presence of anti-DNA (OR 1.34 CI95% 1,03–1,75) and antiSM (OR 1.45 95% CI 1.04–2.02). Never smoker was a protective factor for LN (OR 0.52 CI95% 0.34–0.81).Abstract AB1320 – Table 1Factors associated with Lupus nephritis in a cohort of patients with systemic lupus erythematosus, in Colombia from 2007 to 2015Lupus nephritis ORCI (95%)OR adjust*CI (95%) GenderMale1,271,04–1,551,981,20–3,27Time progress SLEa≥10 years1,371,08–1,741,481,01–2,16Anti SMPositive1,461,10–1,951,451,04–2,02Anti DNA +Positive1,341,05–1,721,341,03–1,75Past or current cigarette consumptionYes1,661,22–2,251,751,14–2,69No previous or current cigarette consumptionYes0,560,41–0,770,520,34–0,81ConclusionsThis study shows a greater association of LN in men. Although there are disparities in the findings worldwide, we believe that other factors typical of this current population such as ancestry and racial mixing may be influencing this finding. No smoking seems to be a protective factor. Awareness of the disclosed risk factor should encourage preventive strategies for LN in SLE patients such as suppression of cigarette smoking.References[1] Pons-estel GJ, Catoggio LJ, Cardiel MH, Bonfa E, Caeiro F, Sato E, et al. Lupus in Latin-American patients: lessons from the GLADEL cohort. 2015;536–45[2] V. A. Seligman, R. F. Lum JLO. Demographic Differences in the Development of Lupus Nephritis: A Retrospective Analysis. Am J Med. 2002;9343(2):726–9.Disclosure of InterestNone decl...

To address the relative lack of information about infections occurring in children following allogeneic hematopoietic stem cell transplants (allo-HSCT) in developing countries, we performed a retrospective cohort study of 139 children who underwent 150 allo-HSCTs in a hospital in Cali, Colombia. Most allo-HSCT (n=144, 96%) were followed by infections over the following year, primarily due to bacteria (4.3 per 1000 patient-days) and CMV (3.3 per 1000 patient-days). Most infections occurred in the first 30 days post HSTC. High mortality (n=44, 31.7%) was associated with infections, but has declined annually from 40% to 17% over the period covered (2012-2017).