Originally published in: Handbook of ATPase. Edited by Masamitsu Futai, Yoh Wada and Jack H. Kaplan. Copyright © 2004 Wiley‐VCH Verlag GmbH & Co. KGaA Weinheim. Print ISBN: 3‐527‐30689‐3 The sections in this article are Gastric H + , K + ‐ ATPase α Subunit of Gastric H + , K + ‐ ATPase β Subunit of Gastric H + , K + ‐ ATPase Regions of Association Between the α and β Subunits Regions of Association of the α Subunits Kinetics of the H + , K + ‐ ATPase Conformations of the H + , K + ‐ ATPase Functional Residues of the H + , K + ‐ ATPase Structural Model of the H + , K + ‐ ATPase Crystal Structure of the H + , K + ‐ ATPase Molecular Modeling of the Gastric H + , K + ‐ ATPase Acid Secretion and the H + , K + ‐ ATPase Inhibitors of the H + , K + ‐ ATPase Substituted Benzimidazoles Substituted Imidazo[1,2α]pyridines and other K + ‐competitive Antagonists Trafficking of the H + , K + ‐ ATPase