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Paleoethnobotanical perspectives are essential for understanding past lifeways yet continue to be underrepresented in Paleoindian research. We present new archaeobotanical and radiocarbon data from combustion features within stratified cultural components at Connley Caves, Oregon, that reaffirm the inclusion of plants in the diet of Paleoindian groups. Botanical remains from three features in Connley Cave 5 show that people foraged for diverse dryland taxa and a narrow range of wetland plants during the summer and fall months. These data add new taxa to the known Pleistocene food economy and support the idea that groups equipped with Western Stemmed Tradition toolkits had broad, flexible diets. When viewed continentally, this work contributes to a growing body of research indicating that regionally adapted subsistence strategies were in place by at least the Younger Dryas and that some foragers in the Far West may have incorporated a wider range of plants including small seeds, leafy greens, fruits, cacti, and geophytes into their diet earlier than did Paleoindian groups elsewhere in North America. The increasing appearance of diverse and seemingly low-ranked resources in the emerging Paleoindian plant-food economy suggests the need to explore a variety of nutritional variables to explain certain aspects of early foraging behavior.

ObjectivePulmonary artery compliance (PAC), estimated as stroke volume (SV) divided by pulmonary artery pulse pressure (PP), may be a predictor of survival in pulmonary arterial hypertension (PAH). Resistance–compliance (RC) time, the product of PAC and pulmonary vascular resistance, is reported to be a physiological constant. We investigated if differences in PAC and RC time exist between pulmonary hypertension (PH) subgroups and examined whether PAC is an independent predictor of transplant-free survival in PAH.MethodsThis was a retrospective analysis of adult PAH (n=532) and chronic thromboembolic PH (CTEPH, n=84) patients enrolled in the US Pulmonary Hypertension Association Registry from 2015 to 2019. PAC and RC time were compared between PH subgroups (connective tissue disease-PAH (CTD-PAH), idiopathic/heritable-PAH (i/h-PAH), drug/toxin-PAH (d/t-PAH)). Cox proportional hazards models were constructed for transplant-free survival, adjusting for REVEAL 2.0 risk score.ResultsThere were no differences in estimated PAC between PAH subgroups, nor between PAH and CTEPH. RC time was shorter in CTEPH compared with PAH (median 0.55 (IQR 0.45–0.64) vs 0.62 (0.52–0.73) s, p<0.0001). RC time was shortest in CTD-PAH when compared with i/h-PAH and d/t-PAH ((0.59±0.18) vs (0.65±0.20) vs (0.73±0.25) s, p=0.0001). PAC was associated with transplant-free survival (HR 0.72, 95% CI 0.55 to 0.94, p=0.02) but was not an independent predictor of outcome after adjustment for REVEAL 2.0 score.ConclusionPAC was similar between PH groups and was not an independent predictor of transplant-free survival in PAH. RC time was different between PH subgroups, challenging RC time constancy.Trial registration numberNCT04071327

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