Few studies have addressed the experiences of Black-White biracial individuals and their responses to discrimination. Exploring minority stress theory, the present study addressed the role of discrimination in the psychological experiences of a unique sample of community-based Black-White biracial Christian adults (N = 217). Six moderated mediation analyses were conducted to examine the associations between discrimination and both psychological well-being and psychological distress. The sequential mediating role of internalized racism and compartmentalization of identity was assessed along with the moderating roles of two forms of religious coping, seeking spiritual support and religious focus, and church support. Religious affiliation and church attendance served as covariates. Discrimination was positively associated with distress and negatively associated with well-being. A significant conditional indirect effect of discrimination on distress through internalized racism and compartmentalized identity was found. Participants with lower compartmentalization of identity and high church support experienced less distress. However, individuals with high compartmentalization of identity and high church support experienced more distress. Religious coping methods of seeking spiritual support and religious focus did not demonstrate significance as moderators in the analyses. Clinical and social implications are considered as well as directions for future research.