Introduction: Secondary hyperparathyroidism is a known and early complication of Chronic Renal Failure (CRF) patients. Renal hyperparathyroidism leads to a host of bone and cardiovascular problems that ultimately can cause fractures, decreased quality of life, and an increased risk of death. Aim: To determine the hospital-prevalence of secondary hyperparathyroidism in CRF patient and establish the correlation between Serum Parathyroid Hormone (PTH) level, Serum calcium and Serum phosphorus level. Materials and Methods: It was a cross-sectional study conducted on 50 patients with CRF at Government Hospital of Bhavnagar, Gujarat. Detailed medical history and blood investigations were done as a tool for data collection. The study variables were described by using statistical parameters like proportion, mean and standard deviation. Correlation coefficient was used for analysing relationship between Serum PTH, calcium and phosphorus. Results: Mean age of the patients was 42.57 (SD 15.19) years with almost equal representation of both genders. Hypertension was the most common aetiological morbidity (62%) among the study participants followed by diabetes (20%). The hospital prevalence of secondary hyperparathyroidism was 86% in Chronic Kidney Disease (CKD). Serum PTH negatively correlated with serum calcium and positively correlated with serum phosphorus with correlation coefficient value of -0.32 and 0.15, respectively. Conclusion: Parathyroid abnormalities and disorders of mineral metabolism are common among patients with CKD. Parathyroid abnormalities detected early may prevent future long term extra-renal complications.