Background: Platelet disorders are commonly encountered clinical problems that may lead to severe bleeding episodes requiring transfusion or hospitalization. Present study is focussed on determining etiopathological profile of thrombocytopenia which is a quantitative platelet disorder. Subjects and Methods: The data for this study was collected by 100 patient evaluation was done by detailed history taking, Clinical examination and relevant investigations using a proforma specially designed for this study in Santokba Durlabhji Hospital, Jaipur. EDTA blood samples were taken for CBC, Hb, APC, estimation and citrated blood in 1:9 dilution were taken for PT & PTTK estimation. Results: In our study incidence of petechiae, ecchymosis & malena was does not depend on age group, but epistaxis & Haemetemesis depends on age group. Here using Pearson Chi-Square test we conclude p value to be significant (p<0.05) thus supporting the basis of this study that incidence of various etiologies of thrombocytopenia varies according to age group. Male & female ratio was 2.12:1was seen in this study. Conclusion: This study is to provide a firm knowledge of the major causes of thrombocytopenia and to form a broad differential diagnosis. Present study infers that various etiologies can be attributed to specific age groups. Moreover different manifestations of thrombocytopenia also vary according to age group.