Left atrial diastolic parameters derived from STE correlate well with the extent of LA fibrosis. Thus, STE may be useful in the noninvasive assessment of LA fibrosis and selection of candidates for RFCA.

Background-Transesophageal echocardiography (TEE) is the gold standard for the exclusion of thrombi in the left atrial appendage (LAA) before ablation for atrial fibrillation. Intracardiac echocardiography (ICE) is used to assist atrial fibrillation ablation; however, it can also be used for LAA imaging. The aim of our study was to determine whether ICE could replace TEE and to identify the optimal ICE placement for LAA visualization. Methods and Results-Seventy-six consecutive patients (56 men; mean age, 55±9.6 years) scheduled for atrial fibrillation ablation underwent TEE before the procedure and LAA assessment by ICE. An 8F AcuNav probe was introduced into right atrium, pulmonary artery, and coronary sinus. LAA structure was analyzed by the echocardiographer and electrophysiologist who were blinded to the results of TEE. ICE probe was positioned in the right atrium in all patients, in the pulmonary artery in 64 of 74 (86%) patients, and in the coronary sinus in 49 of 74 (66%) patients. The LAA was properly visualized in 56 of 64 (87.5%) patients from the pulmonary artery versus 13 of 49 (26%) patients from the coronary sinus (P<0.001). From the right atrium, the whole LAA cavity could not be seen in any patient. In those patients in whom LAA was visualized properly by ICE, a perfect agreement between ICE and TEE was obtained (both techniques detected LAA thrombus in 2 patients and excluded LAA thrombus in the remaining patients). Conclusions-ICE

The new method described in this study was based on consecutive repeated measurements of the resistance of flexor and extensor muscles of the hind foot of the rat to forced flexions and extensions of the foot. Locomotor movements of the rat were restrained with a metaplex box which had a slot for the hind limb. The control muscle tone measured by this method was constant for more than 2 h, and amounted to approx. 25 g for flexor muscles, and approx. 45 g for extensors. Morphine (2.5, 5, 10, 20 mg/kg) enhanced dose-dependently the resistance of flexor muscles up to approx. 45 g, 70 g, 100 g and 140 g, respectively, and the resistance of extensors of the paw up to approx. 100 g, 140 g, 180 g and 240 g, respectively. Haloperidol (5 and 10 mg/kg) enhanced dose-dependently the resistance of flexor muscles up to approx. 45 g and 70 g, respectively, and that of extensors of the foot up to approx. 75 g and 120 g, respectively. Morphine rigidity, measured as resistance of respective muscles to forced movements, was almost completely inhibited by a consecutive injection of 0.2 mg/kg of naloxone. The new method seems to have considerable advantages in comparison with electromyographical (EMG) or other kinds of mechanographical measurements of the muscle tone.