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Purpose A huge amount of diverse data is generated in the Internet of Things (IoT) because of heterogeneous devices like sensors, actuators, gateways and many more. Due to assorted nature of devices, interoperability remains a major challenge for IoT system developers. The purpose of this study is to use mapping techniques for converting relational database (RDB) to resource directory framework (RDF) for the development of ontology. Ontology helps in achieving semantic interoperability in application areas of IoT which results in shared/common understanding of the heterogeneous data generated by the diverse devices used in health-care domain. Design/methodology/approach To overcome the issue of semantic interoperability in healthcare domain, the authors developed an ontology for patients having cardio vascular diseases. Patients located at any place around the world can be diagnosed by Heart Experts located at another place by using this approach. This mechanism deals with the mapping of heterogeneous data into the RDF format in an integrated and interoperable manner. This approach is used to integrate the diverse data of heart patients needed for diagnosis with respect to cardio vascular diseases. This approach is also applicable in other fields where IoT is mostly used. Findings Experimental results showed that the RDF works better than the relational database for semantic interoperability in the IoT. This concept-based approach is better than key-based approach and reduces the computation time and storage of the data. Originality/value The proposed approach helps in overcoming the demerits of relational database like standardization, expressivity, provenance and supports SPARQL. Therefore, it helps to overcome the heterogeneity, thereby enabling the semantic interoperability in IoT.