Ultrasonic vocalizations (USVs) serve important communicative functions in rodents. Different types of USVs can be triggered in the sender, for example, by maternal separation, social interactions, or exposure to predators, and they evoke affiliative or alarming behaviors in recipients. This review focusses on studies evaluating possible links between immunity and USVs. Most studies have been performed in a murine model of maternal immune activation and subsequent evaluation of effects in the offspring. This model has received large attention in recent years because it mimics behavioral abnormalities observed in certain human neuropsychiatric disorders, including autism spectrum disorder. Although there is still some controversy, the results indicate that stimulation of the immune system of mice and rats during pregnancy affects ultrasonic calling in pups. Few studies are available on immunization during adulthood and USVs. In most cases, immune stimulation led to disease, complicating conclusions about a possible direct link between vocalization and immunity. Although much work is still needed, this is certainly a rather new and promising aspect of interactions between the immune system and behavior.

Interactions between T cells and noradrenergic pathways were investigated using athymic nude mice as a model. Higher noradrenaline (NA) concentrations and increased density of noradrenergic fibers were found in the spleen and hypothalamus, but not in the kidney, of 21-day-old Foxn1(n) (athymic) mice, compared with Foxn1(n) /Foxn1(+) (heterozygous) littermates. Although no differences in nerve growth factor concentrations were detected, significantly higher brain-derived neurotrophic factor concentrations were found in the spleen and hypothalamus of athymic mice compared with the controls. All of these alterations were abrogated in Foxn1(n) mice reconstituted by thymus transplantation at birth. These results suggest that T lymphocytes or their products can induce (1) a decrease in the number and activity in splenic sympathetic nerve fibers; (2) a decrease in NA content in the hypothalamus, which, in turn, may influence the pituitary-adrenal axis and the descending neural pathways associated with the autonomic nervous system; and (3) changes in neurotrophin concentration in the spleen and hypothalamus.

Programmed identification of white platelets (WBCs) stays an uncertain issue in medicinal imaging. The first step in this algorithm is to detect a white blood cell (Lymphocyte) and then segments the Cytoplasm and Nucleus in this cell. This was done by using image processing Techniques. The suggested method depending on the binary conversion of red, blue and hue compounds depending on threshes values. These values were calculated from histogram analysis within specific ranges. The proposed algorithm was compared with several other algorithms for detection by using an accuracy scale in the detection. where the proposed algorithm obtained a high distinction accuracy reached 98% compared to other methods.

Detection of white blood cells (WBCs) automatically is an important issue that has many applications in the field of medical imaging, in this research, we tend to detect white blood cells depending on the Ycbcr color space. The proposed method has been used for the binary conversion of color compounds cbcr depending on the certain threshold limits. In the experimental results from microscopy images of blood samples, the proposed algorithm was compared with several other algorithms for detection by using a quality scale that compares manual cell count with automatic detection of algorithms where the proposed algorithm obtained a high distinction accuracy reached to 100% compared to other methods.