No abstract

Demand for data storage is growing exponentially, but the capacity of existing storage media is not keeping up. Using DNA to archive data is an attractive possibility because it is extremely dense, with a raw limit of 1 exabyte/mm 3 (10 9 GB/mm 3 ), and long-lasting, with observed half-life of over 500 years.This paper presents an architecture for a DNA-based archival storage system. It is structured as a key-value store, and leverages common biochemical techniques to provide random access. We also propose a new encoding scheme that offers controllable redundancy, trading off reliability for density. We demonstrate feasibility, random access, and robustness of the proposed encoding with wet lab experiments involving 151 kB of synthesized DNA and a 42 kB randomaccess subset, and simulation experiments of larger sets calibrated to the wet lab experiments. Finally, we highlight trends in biotechnology that indicate the impending practicality of DNA storage for much larger datasets.

No abstract

No abstract

Many advanced programming tools---for both end-users and expert developers---rely on program synthesis to automatically generate implementations from high-level specifications. These tools often need to employ tricky, custom-built synthesis algorithms because they require synthesized programs to be not only correct, but also optimal with respect to a desired cost metric, such as program size. Finding these optimal solutions efficiently requires domain-specific search strategies, but existing synthesizers hard-code the strategy, making them difficult to reuse. This paper presents metasketches, a general framework for specifying and solving optimal synthesis problems. metasketches make the search strategy a part of the problem definition by specifying a fragmentation of the search space into an ordered set of classic sketches. We provide two cooperating search algorithms to effectively solve metasketches. A global optimizing search coordinates the activities of local searches, informing them of the costs of potentially-optimal solutions as they explore different regions of the candidate space in parallel. The local searches execute an incremental form of counterexample-guided inductive synthesis to incorporate information sent from the global search. We present Synapse, an implementation of these algorithms, and show that it effectively solves optimal synthesis problems with a variety of different cost functions. In addition, metasketches can be used to accelerate classic (non-optimal) synthesis by explicitly controlling the search strategy, and we show that Synapse solves classic synthesis problems that state-of-the-art tools cannot.