The National COVID-19 Chest Imaging Database (NCCID) is a repository of chest radiographs, CT and MRI images and clinical data from COVID-19 patients across the UK, to support research and development of AI technology and give insight into COVID-19 disease https://bit.ly/3eQeuha

A recent U.K. National Screening Committee review (1,2) concluded that evidence was insufficient to support the implementation of artificial intelligence (AI) in routine breast cancer screening. The review identified limited evidence on sources of variability, impact on interval cancers (ICs) detected between screening cycles, and performance of a preset threshold to classify recall or no recall. In addition, evidence for the transferability of AI models is inconsistent (3-5).We evaluated commercial AI software (6) by using data from a U.K. screening program to determine whether its performance transferred to an external dataset generated with different mammography equipment. The AI software is Conformité Européenne marked, indicating compliance with applicable European Union regulations. This study evaluates the generalizability of the AI tool by using consecutively acquired clinical data, comparing stand-alone performance to the dual reporting system in the U.K. screening service. Materials and Methods SampleThe Proportionate Review Subcommittee of the London-Bloomsbury Research Ethics Committee approved this retrospective study (reference no. 20/LO/0563). Secondary use of de-identified data negated the requirement for individual consent. Public Benefit and Privacy Panel approval was obtained (reference no. 1920-0258).National Health Service (NHS) Grampian clinical data and mammograms were collected from the Scottish Breast Screening Service (SBSS) (February 12, 2016-March 31, 2020. Full-field digital mammograms were acquired with five mammography units of the same make and model (Selenia Dimensions; Hologic) with no known differences at study commencement. All units conform to NHS breast cancer screening quality standards (7). The standard imaging protocol consisted of two views per breast (craniocaudal and mediolateral oblique). As part of routine screening,

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