The ambruticins are a family of polyketide natural products which exhibit potent antifungal activity. Gene knockout experiments are in accord with the proposal that the tetrahydropyran ring of the ambruticins...
In this review, methods for the selective intramolecular epoxide ring opening (IERO) of 4,5-epoxy-alcohols are discussed as well as biosynthetic pathways to tetrahydropyran-containing natural products which utilise IERO reactions.
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