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Flows from river basins in northwestern Canada have been rising in the last two decades as a result of climate warming. In the wetland‐dominated basins that characterise the southern margin of permafrost, permafrost thaw and disappearance, and resulting land‐cover change, is occurring at an unprecedented rate. The impact of this thaw on runoff generation in headwater basins is poorly understood. Permafrost thaw has the potential to fundamentally alter the cycling and storage of moisture inputs in this region by altering the type and relative proportions of the major land‐cover types, such as peat plateaus, channel fens and flat bogs. This paper examines streamflow changes in the four Water Survey of Canada gauged river basins (152–2050 km2) in the lower Liard River valley, Northwest Territories, Canada, a region where permafrost thaw has produced widespread loss of forest and concomitant expansion of permafrost‐free wetlands. Annual runoff in the lower Liard Valley increased by between 112 and 160 mm over the period of 1996–2012. The Mann‐Kendall non‐parametric statistical test and the Kendall‐Theil robust line were used to ascertain changes in streamflow. Historical aerial photographs from 1977 and high‐resolution satellite imagery (WorldView 2) from 2010 were used to measure the rate and pattern of permafrost thaw in a representative 6 km2 area of Scotty Creek. Permafrost thaw‐induced land‐cover change is both increasing the adjacency between runoff producing and transmitting land cover types and transforming certain land covers that store water into ones that produce runoff. This land‐cover change was found to be the single most important factor (37–61 mm) contributing to the observed increase in river discharge. Other contributing factors include increases in plateau runoff contributing areas (20–32 mm), increases in annual effective precipitation depth (18–30 mm), contribution of water from the melt of ice within permafrost (9 mm) and increases in baseflow (0.9–6.8 mm). Although runoff has significantly (p < 0.05) increased in all four basins, the largest increases are in basins with a relatively high cover of flat bogs. Copyright © 2014 John Wiley & Sons, Ltd.

Obesity is a growing epidemic and a common problem among reproductive-age men that can both cause and exacerbate male-factor infertility by means of endocrine abnormalities, associated comorbidities, and direct effects on the fidelity and throughput of spermatogenesis. Robust epidemiologic, clinical, genetic, epigenetic, and nonhuman animal data support these findings. Recent works in the burgeoning field of epigenetics has demonstrated that paternal obesity can affect offspring metabolic and reproductive phenotypes by means of epigenetic reprogramming of spermatogonial stem cells. Understanding the impact of this reprogramming is critical to a comprehensive view of the impact of obesity on subsequent generations. Furthermore, and perhaps more importantly, conveying the impact of these lifestyle changes on future progeny can serve as a powerful tool for obese men to modify their behavior. Reproductive urologists and endocrinologists must learn to assimilate these new findings to better counsel men about the importance of paternal preconception health, a topic recently being championed by the Centers for Disease Control and Prevention.

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Purpose Injection of mitomycin C may increase the success of transurethral incision of the bladder neck for the treatment of bladder neck contracture. We evaluated the efficacy of mitomycin C injection across multiple institutions. Materials and Methods Data on all patients who underwent transurethral incision of the bladder neck with mitomycin C from 2009 to 2014 were retrospectively reviewed from 6 centers in the TURNS. Patients with at least 3 months of cystoscopic followup were included in the analysis. Results A total of 66 patients underwent transurethral incision of the bladder neck with mitomycin C and 55 meeting the study inclusion criteria were analyzed. Mean ± SD patient age was 64 ± 7.6 years. Dilation or prior transurethral incision of the bladder neck failed in 80% (44 of 55) of patients. Overall 58% (32 of 55) of patients achieved resolution of bladder neck contracture after 1 transurethral incision of the bladder neck with mitomycin C at a median followup of 9.2 months (IQR 11.7). There were 23 patients who had recurrence at a median of 3.7 months (IQR 4.2), 15 who underwent repeat transurethral incision of the bladder neck with mitomycin C and 9 of 15 (60%) who were free of another recurrence at a median of 8.6 months (IQR 8.8), for an overall success rate of 75% (41 of 55). Incision with electrocautery (Collins knife) was predictive of success compared with cold knife incision (63% vs 50%, p=0.03). Four patients experienced serious adverse events related to mitomycin C and 3 needed or are planning cystectomy. Conclusions The efficacy of intralesional injection of mitomycin C at transurethral incision of the bladder neck was lower than previously reported and was associated with a 7% rate of serious adverse events.