Bedrock fracture systems facilitate weathering, allowing fresh mineral surfaces to interact with corrosive waters and biota from Earth's surface, while simultaneously promoting drainage of chemically equilibrated fluids. We show that topographic perturbations to regional stress fields explain bedrock fracture distributions, as revealed by seismic velocity and electrical resistivity surveys from three landscapes. The base of the fracture-rich zone mirrors surface topography where the ratio of horizontal compressive tectonic stresses to near-surface gravitational stresses is relatively large, and it parallels the surface topography where the ratio is relatively small. Three-dimensional stress calculations predict these results, suggesting that tectonic stresses interact with topography to influence bedrock disaggregation, groundwater flow, chemical weathering, and the depth of the "critical zone" in which many biogeochemical processes occur.

The zoster vaccine induced a significant increase in VZV-CMI and VZV antibody. The magnitude and duration of the boost in VZV-CMI in vaccine recipients and the relationship of this boost to age paralleled the clinical effects of the vaccine observed during the efficacy trial. These findings support the hypothesis that boosting VZV-CMI protects older adults against herpes zoster and postherpetic neuralgia.

Higher VZV CMI at HZ onset was associated with reduced HZ severity and less postherpetic neuralgia. Higher antibody titers were associated with increased HZ severity and occurrence of postherpetic neuralgia. HZ and zoster vaccine generated comparable VZV CMI.

Observing the critical zone (CZ) below the top few meters of readily excavated soil is challenging yet crucial to understanding Earth surface processes. Near‐surface geophysical methods can overcome this challenge by imaging the CZ in three dimensions (3‐D) over hundreds of meters, thus revealing lateral heterogeneity in subsurface properties across scales relevant to understanding hillslope erosion, weathering, and biogeochemical cycling. We imaged the CZ under a soil‐mantled ridge developed in granitic terrain of the Laramie Range, Wyoming, using data from five boreholes and a 3‐D volume (970 by 600 by 80 m) of seismic velocities generated by ordinary kriging of 25 two‐dimensional seismic refraction transects. The observed CZ structure under the ridge broadly matches predictions of two recently proposed hypotheses: the uppermost surface of weathered bedrock is consistent with subsurface weathering driven by bedrock drainage and subsurface topography defining the top of unweathered protolith is consistent with fracturing predicted from topographic and regional stresses. In contrast, differences in slope aspect along the ridge are too subtle to explain observed variations in regolith structure. Our observations suggest that multiple processes, each of which may dominate at different depths, work in concert to regulate deep CZ structure.