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Physician to the Liverpool North Dispensary. IN THE LANCET of the 31st of August, 1844, my attention was drawn to the treatment of acute inflammation by large blisters, from observing some excellent practical remarks on the subject by Dr. Henry Bennet, in which he has shewn that they may be safely and beneficially used at an earlier period of acute inflammatory diseases, especially of those of the organs contained in the thoracic cavity, than they are generally employed. The kind of cases to which blisters are best suited, as well as the period of the disease at which they may be most advantageously applied, are matters of great practical importance, owing to the extent to which they are used; and I take, therefore, the opportunity of snaking some observations on these points, as well as on the effects produced by bleeding, blisters, and mercury, on the different constituents of the blood. My attention was first particularly directed to the safety and advantages of applying blisters in the early period of acute-inflammatory diseases, from observing, when in Paris, nearly five years ago, the treatment adopted by M. Gendrin in pneumonia, and other acute inflammations, and I am glad to find that the results of his mode of treatment have been made known to the profession by one who has had the opportunity of closely observing it while holding, during nearly three years, the office of

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