Background Degos disease is a very rare syndrome with multisystem vasculopathy of unknown cause. It can affect the skin, gastrointestinal tract, and central nervous system. However, other organs such as the kidney, lungs, pleura, and liver can also be involved. Case presentation A 35-year-old Hindu woman presented to our dermatology outpatient department with complaints of depigmented painful lesions. A skin punch biopsy taken from the porcelain white atrophic papules which revealed features of Degos disease. Conclusion The diagnosis of Degos disease is usually based on the presence of the pathognomonic skin lesions and a tissue biopsy demonstrating a wedge-shaped area of necrosis with thrombotic occlusion of the small arterioles. No specific treatment is currently available for this disease.

Background Periodontitis can trigger and perpetuate inflammation in several chronic inflammatory diseases. The association of periodontitis with psoriasis has been investigated earlier, but data are incomplete and the influence of confounders has not been fully evaluated. We examined the relationship of dental and periodontal health parameters in patients with psoriasis and/or psoriatic arthritis. Methods This hospital-based cross-sectional analytical study was conducted in patients with chronic plaque psoriasis, psoriatic arthritis or both, and compared with controls. Dental and periodontal health parameters were assessed based on the WHO oral health assessment method. Multivariate logistic regression was done on variables with significant or near-significant values to find the association between periodontitis and psoriasis and/or psoriatic arthritis after adjusting for confounders. Results Psoriasis and/or psoriatic arthritis were independently and significantly associated with periodontal pockets ≥4 mm in depth. Limitations Causality and temporal relationship cannot be established as this was a cross-sectional study. As in all observational studies, the possibility of unmeasured or unknown confounders exists. Psoriatic arthritis was present only in a small subset of patients. Conclusion Patients with psoriasis and/or psoriatic arthritis have significant periodontal inflammation. This needs to be addressed by dental examination and intervention.

Dowling-Degos disease (DDD) is an uncommon autosomal dominant genodermatosis that resides in the spectrum of diseases presenting with reticulate pigmentation. This disease has varied phenotypic expressions, the classical presentation being reticular pigmentation of flexures involving the axilla, submammary folds, inguinal folds, and neck. Follicular DDD is a variant of DDD with a unique presentation of folliculocentric papules, macules, pits, and comedones associated with the characteristic histological findings of follicle-centered, pigmented, branching, antler horn-like rete ridges sparing the interfollicular epidermis. Due to the rarity and paucity of data about this entity, we describe this case of a 28-year-old female who presented with perioral pitted scars and multiple hyperpigmented folliculocentric comedo-like papules over the face, neck, cubital fossa, and upper trunk, unaccompanied by the typical non-follicular, reticulate flexural hyperpigmentation, which clinically posed a diagnostic challenge. The diagnosis was confirmed by histopathology. We intend to increase clinicians’ cognizance with respect to the unique clinical and histopathologic presentation of follicular DDD. More genetic studies could bring more understanding of this complex spectrum.

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agar (Flukaâ Analytical) containing 0.05% chloramphenicol (Inlab) and Mycobiotic agar (Difco), in triplicate, and incubated at 25°C for 45 days.None of the 579 samples of nail polish (of different brands and colors) showed characteristic fungal growth for dermatophytes of the genera Trichophyton, Microsporum, and Epidermophyton and yeasts of the genus Candida sp; that is, all the cultured samples tested negative for these microorganisms. In a previous work, no fungal growth was detected on plates inoculated with nail polish contaminated with 2 9 10 3 to 6 9 10 3 UFC of T. rubrum/ml of nail polish 3 or nail polish routinely used at nail salons. 4 Although different methodologies were used, nail polish contains highly toxic chemicals such as toluene, xylene, formaldehyde, chromium, and nickel. Furthermore, the preservatives and biocides present in nail polish, including sodium benzoate, potassium sorbate, benzoic acid, and phenols, decrease contamination with microorganisms.Therefore, our findings suggest that nail polish contains chemical components that inhibit microorganism growth, so it is not a source of fungi that causes onychomycosis due to dermatophytes, yeasts of the genus Candida, and non-dermatophyte filamentous fungi.