Background: Netrin-1 can either attract or repel neuronal growth cones. Results: The ezrin/radixin/moesin proteins mediate interaction between protein kinase A (PKA) and deleted in colorectal cancer (DCC, a netrin receptor), which controls growth cone tropism. Conclusion: Localized PKA signaling governs axon guidance behavior toward netrin. Significance: This interaction provides insight into the signals governing axon pathfinding, neural development, and potentially other DCC-related functions.