A scientific evaluation of these historical documents can give an insight into the ideas of the past and be valuable in finding new data on clinical use of the mucilages that should lead to future opportunities to investigate their potential medicinal use.

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Context: Jaundice is a common gastrointestinal system disorder globally. Considering the potential of herbal remedies in traditional medical systems, this study was performed to explore medicinal plants used for the treatment of jaundice in the Canon of medicine. Evidence Acquisition: This narrative review was done on one of the most important textbooks in traditional Persian medicine. Different keywords, like Yaraghan and Zardi, were searched in the book, and a list of plants used was prepared. We searched for recent literature to find any supportive evidence to find the established mechanism of action, as well. Results: At the end of the study, 32 plants were found in the Canon of medicine, which most of them had at least one experimental or clinical study clarifying their mechanism of action to treat jaundice or decrease bilirubin. Conclusions: There are potential remedies in traditional Persian medicine resources, which may be useful in future trials to treat jaundice.