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The chapter presents the problem of quality of life modeling in the Czech Republic based on classification methods. It concerns a comparison of methodological approaches; in the first case the approach of the Institute of Sociology of the Academy of Sciences of the Czech Republic was used, the second case is concerning a project of the civic association Team Initiative for Local Sustainable Development. On the basis of real data sets from the institute and team initiative the authors synthesized and analyzed quality of life classification models. They used decision tree classification algorithms for generating transparent decision rules and compare the classification results of decision tree. The classifier models on the basis of C5.0, CHAID, C&RT and C5.0 boosting algorithms were proposed and analyzed. The designed classification model was created in Clementine.