BackgroundTo document the status of imported malaria infections and estimate the costs of treating of patients hospitalized with the diagnosis of imported malaria in the Slovak Republic during 2003 to 2008.Case studyCalculating and comparing the direct and indirect costs of treatment of patients diagnosed with imported malaria (ICD-10: B50 - B54) who used and not used chemoprophylaxis. The target sample included 19 patients diagnosed with imported malaria from 2003 to 2008, with 11 whose treatment did not include chemoprophylaxis and eight whose treatment did.ResultsThe mean direct cost of malaria treatment for patients without chemoprophylaxis was 1,776.0 EUR, and the mean indirect cost 524.2 EUR. In patients with chemoprophylaxis the mean direct cost was 405.6 EUR, and the mean indirect cost 257.4 EUR.ConclusionsThe analysis confirmed statistically-significant differences between the direct and indirect costs of treatment with and without chemoprophylaxis for patients with imported malaria.

Urinary incontinence (UI) has substantial and important impacts on health-related quality of life. The purpose of this research is to report the psychometric performance of 15 different language versions of the Incontinence-specific Quality of Life (I-QOL) measure, a patient-reported outcome measure specific to stress, urge and mixed urinary incontinence. The multi-national dataset consisted of data from four clinical trials for stress incontinent females and from two additional population studies, enrolling women with stress, urge and mixed UI. All enrolled patients completed the I-QOL and comparative measures at baseline. The clinical trial populations had multiple administrations up to 12 weeks, and the two population studies included a shorter retest. Country-specific psychometric testing for validity, reliability, and responsiveness followed standardized procedures. Confirmatory factor analyses were performed to assess the I-QOL subscales. The I-QOL measurement model was confirmed as three subscales. Summary and subscale scores for the 15 versions were internally consistent (alpha values = 0.91-0.96) and reproducible (ICC = 0.72-0.97). Using changes in the independent measures of incontinence episode frequency standardized response means were predominantly strong (ranged 0.71-1.05) across 13 versions (out of 15) in association with these measures and effect sizes. These additional language versions of the I-QOL instrument demonstrate psychometric properties similar to the original version. The I-QOL has shown good results in both community studies and clinical trials with varying types and severity of urinary incontinence. It is a reliable and valid measure of HRQOL, suitable for use in a variety of international settings.

The aim of this cross-sectional study was to monitor the prevalence of symptoms of stress (SUI) and mixed urinary incontinence (MUI) in sportswomen performing high-impact exercises. A further objective was to compare the symptoms of urinary incontinence (UI) and quality of life in sportswomen. We used the International Consultation on Incontinence Questionnaire (ICIQ-SF), the Overactive Bladder Questionnaire (OAB-q), the Urinary Incontinence Quality of Life Scale (I-QOL) and the International Physical Activity Questionnaire (IPAQ), short version. The group consisted of 503 sportswomen with a mean age of 21.1±3.6. The response rate was 71.15%. ICIQ-SF results confirmed mild difficulties with urine leakage in 72 (14.3%) sportswomen. Urinary leakage was not noted in 431 (85.7%) sportswomen. The OAB-q and I-QOL showed a significant difference, with pronounced symptoms of UUI and worse QOL in the group of sportswomen with urine leakage (p<0.000). The I-QOL recorded significantly worse parameters in the group of sportswomen with urine leakage (p<0.000). Prevalence of SUI was found in 68 (13.52%), and MUI was found in 4 (0.80%) sportswomen. Every seventh sportswoman (14.3%) in the study group had reported problems with UI when practising high-impact sporting activities, with a negative impact on QOL.

The purpose of this study was to analyse attitudes, motivation, and reasons for hesitancy toward COVID-19 vaccination among healthcare workers (HCWs) in northern Slovakia. A cross-sectional study was conducted between 30 August 2021 and 30 September 2021. An anonymous questionnaire was administered. The study was completed by 1277 employees. Multivariate logistic regression was used to identify predictors of COVID-19 vaccination status. A total of 1076 (84.3%) were vaccinated, and 201 (15.7%) were unvaccinated. Physician job type (OR = 1.77; CI95 1.13–2.78), history of COVID-19 (OR = 0.37; CI95 0.26–0.37), influenza vaccination at any time (OR = 1.97; CI95 1.12–3.46), compulsory vaccination for HCWs (OR = 9.15; CI95 2.92–28.62), and compulsory vaccination for selected groups (OR = 9.71; CI95 2.75–34.31) were the predictors significantly associated with COVID-19 vaccination acceptance. Non-physician HCWs, employees in hospitals, and employees without a history of COVID-19 significantly more distrusted the efficacy of vaccines against COVID-19. Results of our study confirmed that physicians have higher vaccination rates and lower hesitance to get vaccinated than non-physician HCWs. HCWs play an important role in influencing vaccination decisions and can be helpful in vaccine advocacy to the general public.

The aim of this meta-analysis was to evaluate the prevalence of COVID-19 vaccination among medical students worldwide. Three electronic databases, i.e., PubMed, Scopus, and Web of Science (WoS), were used to collect the related studies according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The study population included undergraduate medical students who had already been vaccinated reported in original articles published between January 2020 and December 2021. The heterogeneity of results among studies was quantified using the inconsistency index I2. Publication bias was assessed by using Egger’s test. Six cross-sectional studies with 4118 respondents were included in this study. The prevalence of COVID-19 vaccination was 61.9% (95% CI, 39.7–80.1%). There were no statistical differences between gender and vaccination acceptance, 1.038 (95% CI 0.874–1.223), and year of study and vaccination acceptance, 2.414 (95% CI, 0.754–7.729). The attitudes towards compulsory vaccination among healthcare workers can be determined by a prevalence of 71.4% (95% CI, 67.0–75.4%). The prevalence of COVID-19 vaccination among medical students was at a moderate level. Placing a greater emphasis on prevention seems essential in the medical curriculum.