We confirmed that mutations in KISS1 and KISS1R are not a common cause for ICPP.

Neonatal lupus erythematosus (NLE) is a rare autoimmune disease due to a passive transfer of maternal autoantibodies to the fetus. The clinical spectrum is variable and includes skin lesions, cardiac, hematological, or hepatobiliary disorders. We report an NLE case presenting with skin eruption that was initially considered as tinea.

Flora in the Republic of Macedonia comprises about 3200 species in 147 families. According to some sources there are 115 endemic higher plants, of which, 114 belong to gymnosperm. According to other sources, there are 135 species of endemic plants and about 111 of which are local endemic species and 24 are stretched in the border mountains. The exact number has not been determined yet. Eastern part of Macedonia, east of the river Vardar almost poses no endemics, while the rest of the territory, west of the Vardar is very rich in such species. The richest areas with endemic plants are Galicica Mountain, Treska River Gorge and the lowlands surrounding the city of Prilep. Despite the wealth of endemic and relict species, any pharmacognostical data for these plants have not been published yet. Of all these endemic species, 30 could be pharmaconosticly interesting for future investigation of the chemical composition, isolation of potentially active substances and testing biological-pharmacological activity. Modern analytical techniques utilized in the examination of the chemistry of medicinal plants and natural products require a very small amount of material does not pose a risk of endangering endemic species. An additional challenge is the development of an appropriate program for the protection of all endemic, pharmaconosticly interesting species.

DiGeorge’s syndrome is a 22q11.2 deletion leading to abnormal embryogenesis of pharyngeal arches and it is manifesting in a variety of clinical signs and symptoms. The spectrum of anomalies varies from minor facial dysmorphism and cleft palate to a broad spectrum of cardiovascular anomalies, thymic disfunction and immune deficiencies, hypocalcemia due tohypoparathyroidism,growth and developmental delay and speech disturbances. Cardiovascular anomalies might include right sided aortic arch, aberrant vesiclesand vascular ring. Here we present an atypical case of partial DiGeorge’s syndrome with feeding and swallowing difficulties and laryngeal stridor in the neonatal period. Early presentation in this period is usually due to severe hypocalcemia and cardiac disease. Feeding difficulties in a preterm baby needed clinical assessment skills in order to establish the diagnosis and delineate it from feeding difficulties usually seen in preterm babies. Esophagogram (barium X Ray) showed antero-posterior oblique impression towards the right side, the latero- lateral view showed impression on the rare side, suspected to be esophageal sub stenosis due to vascular anomaly, aberrant right subclavian arteryand suspectedthymic hypoplasia. We report a 9-year follow up periodbya team of subspecialists. The child had two surgeries due to aberrant vessel and velopharyngeal deficiency. Optimal management of patients with DiGeorge’s syndrome requires a multidisciplinary teamwhichshould include a cardiologist, immunologist, geneticist, speech/language therapist, endocrinologist and other subspecialists depending on patient`'s phenotype.

Neonatal lupus erythematosus (NLE) is a rare autoimmune disease due to a passive transfer of maternal autoantibodies to the fetus. Clinical spectrum is variable and includes skin lesions, cardiac, hematological, or hepatobiliary disorders. We report a NLE case presenting with skin eruption that was initially considered as tinea.