This study was supported by grants from the intramural innovative medical research program of Muenster University medical faculty (grant no. KE121201 to C.K.) and the German Research Foundation (DFG, grant no. WI3176/2-1 to H.W. and grant no. Fo354/3-1 to D.F.). Disclosure of potential conflict of interest: C. Kessel & D. Foell have filed a patent application on ''means and methods for diagnosing and treating inflammatory disorders'' regarding proinflammatory S100A12 homomultimers (WO 2016/178154 A1). The rest of the authors declare that they have no relevant conflicts of interests.