Games edukasi menciptakan suasana menyenangkan dalam pembelajaran IPA. Penelitian ini bertujuan untuk mengembangkan game Science Adventure untuk meningkatkan keterampilan pemecahan masalah. Penelitian ini menggunakan metode Research and Development (RD) yang mengadaptasi model 4D-Thiagarajan yakni Define, Design, and Develop. Subjek penelitian ini yaitu siswa kelas VII D SMP N 13 Semarang (N=32). Teknik analisis data yang digunakan yaitu kuantitatif-deskriptif, berupa rerata skor validasi. Hasil penelitian menunjukan tingkat kelayakan game science adventure yang telah dikembangkan sebesar 92,5% pada aspek materi; dan 95,25%  pada aspek media sedangkan berdasarkan tes keterampilan memecahkan masalah, didapatkan ketuntasan klasikal 100% (sangat baik) dengan rata-rata nilai siswa 82,8. Hal ini menunjukkan bahwa media game science adventure layak dan dapat meningkatkan keterampilan pemecahan masalah.

ABSTRACT Acne is a major problem for teenagers, especially at puberty. Guava leaves (Psidium guajava Linn .) are plants that contain several secondary metabolites, including the tannins, triterpenoids, glycosides, and flavonoids, which have anti-acne activity. So far, acne reduction is still being done using synthetic cosmetics. However, synthetic cosmetics often irritate, so that herbal cosmetics are an alternative. Formulation of herbal cosmetics for acne need to do. This study aims to determine the best formula for anti-acne cleanser emulgel from the ethanol extract of guava leaves based on the physical evaluation. Guava leaf extract as obtained by the maceration method uses ethanol as a solvent, then an emulgel was prepared with an extract concentration of F1 (5%) and F2 (10%). Emulgel characteristics were determined by physical evaluation including organoleptic, pH, emulsion type, viscosity, spreadability, homogeneity, foam stability, power clean, and hedonism. The best formula was determined by the number of tests that meet the requirements and are liked by consumers. The results had shown F1 is the best formula based on physical evaluation. Keywords: Acne, emulgel, guava leaves, physical evaluation

At this time, community does not understand classes of drugs that can be purchase or stored at home. This can have two impacts, positive and negative. The positive impact is community become more responsive to health, while the negative impact is increasing use of drugs which raises problems related to how to get, use, store and dispose of drugs properly or commonly known as Dagusibu. This community service activity aims to educating housewives as "pharmacists" in the household regarding how to get, use, store, and dispose of drugs properly in Kedanyang Village RT/RW 003/003, Kebomas, Gresik. Method that we use in this community service is counseling and training using property and followed with monitoring. We use questionnaire for monitoring a month after counseling and training. Our method to counseling and training involve several variable, including Question of 5”O”, Get, Use, Save and Discard (Dagusibu). The result shows that this activity is effective with the percentage of correct answer for each variable are above 75%, including question about 5”O" as much as 97%, get 84.38%, use 87.14%, save 76%, and waste 93%. This proved that the method chosen in this community service is appropriate, where the community still remember and understand.<br /><br />

Cyclooxygenase is an enzyme that plays a role in the formation of prostaglandins, which can cause inflammation and pain when overexpressed. This study aims to determine the interaction between COX-2 macromolecules (receptors) with their ligands, namely indomethacin and diclofenac in silico using the Molecular Docking method. The COX-2 receptor was downloaded in the form of a 3D structure from the RCSB GDP with code 5F19. Diclofenac Ligand and Indomethacin were downloaded in the form of a 3D structure from the RCSB GDP with 4ZBQ code and 4IK7 code. The results showed that the interaction between COX-2 and indomethacin was the interaction of hydrogen, which linked indomethacin with amino acid Leu531 and steric interactions between indomethacin and amino acids Trp387, Tyr385, Tyr355, Leu352, and Val523. The interaction of [COX-2 – Indomethacin] produces a value of ∆G of -103.136 kcal/mol, and the value of RMSD is 1.244 Å. Whereas, the interaction that occurs in COX-2 with diclofenac is the steric interaction that happens between diclofenac with amino acids Leu390, Trp387, Gln203, His388, His207, and Thr206. The interaction parameter between [COX-2-Diclofenac] obtained ∆G value of -7.843 kcal/mol and an RMSD value of 2.07851 Å.

Usually, papaya leaf can be used as malaria disease treatment, prevent acne, appetite enhancer, milk supplement even making a toothache. In this research, papaya leaf is made as snack chips. The ingredients of papaya leaf’s chips are papaya leaf’s, rice flour, tapioca flour, red chili pepper, salt, eggs, guava leaf’s, clay, coriander, candlenut, flavorings, cooking oil, garlic, and water. The papaya chips also treat by organoleptic tests that consist of 5 criteria includes color, smell, texture, appearance, a taste of spices and moisture content test. The process of making papaya leaf’s chips include wash the papaya leaf, cutting, boiling used clay and guava then add salt to remove the bitter taste. The next step is making flour dough, frying, and slicing. The results of the organoleptic test 90% mean that consumers are very like papaya chips and the results of moisture content test are 4.564%.