Stakeholders share many concerns regarding the relationships between information technologies and clinical guideline use. However, administrators, physicians, and nurses hold different opinions about specific facilitators and barriers. Health professionals' disparate perceptions could undermine guideline initiatives. Implementation plans should specifically incorporate actions to address these barriers and enhance the facilitative aspects of information technologies in clinical practice guideline use.

The study uddressed issues surrounding the pntient j . recognition of whether a symptom is d r u g or niseiise-related. Studies have demonstrated that the infornmtion the Iaypopulation has about illness can be organized into Jive categories: identity (symptoms and label), cause. time course. consequences. and cure. These elements, termed illness representations or prototyes. facilitate patient interpretation and response to symptoms as they occur the ore tic ally^ patients may have such a framework f o r interpretation of symptoms thrit thev considered adverse drug reactions. The purpose of this study was to explore whether ( i n adverse drug reaction ( A I M ) prototype esists. A self-administered questionnaire wus used t o elicit the subject i perceptions and awareness of adverse drug reactions. Subjects n'ere also asked to make judgments about severity of ADRs and frequency of piirticulur symptoms as drug-related effects. The study population was a sample of 338 adults visiting afnmi1.v practice clinic over a four-week period. A majority of the respondents reported personal e.rperienc-e of an ADR and described the event with information nhich was consistent with the Jive categories. Subjects who reported ADR e-rperience believed drug reactions occur more frequently and are less severe than those without such crperience. Results also indicated that people have knowledge about ADR symptoms that is substantially accurate. and may use a protofipe to facilitate identification of svmptonis as iin adverse ej'ect.

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SUMMARYBackground: Collagenous colitis is typified by chronic watery diarrhoea and characteristic histological alterations of the colonic mucosa without endoscopic abnormalities. Budesonide, a corticosteroid with high first-pass metabolism has been examined in collagenous colitis, but studies to date have had small numbers, and relatively low statistical power. Aim: A meta-analysis of existing published trials was undertaken to evaluate the treatment effect of budesonide in collagenous colitis. Methods: All pertinent literature sources were searched for published reports in English of budesonide use in

In this highly educated, health-literate sample, a majority did not understand the pharmacy-relevant educational pamphlet despite adequate performance on a standard measure of health literacy. The cloze procedure can be used to assess comprehension of educational materials, solicit feedback from intended users, and guide the revision of educational materials.