Dandruff is a common scalp disorder affecting almost 50% of the human population caused by M. globosa and M. furfur which are two naturally occurring skin fungus. This review discusses in detail the anatomy, pathophysiology, causes and symptoms, and treatment methods available for Dandruff. It also highlights the herbal ingredients with anti-dandruff activity that are used in novel shampoo formulations as a treatment strategy. This review discusses various bioactivities through which these compounds treat dandruff such as anti-inflammatory, antifungal, as well as their mechanism of action. Due to its amphibious status, dandruff is the most commercially exploited skin and scalp disorder/disease by personal care enterprises because there is less medical intervention for treatment.