This study explores success among Native Americans in science, technology, engineering, and mathematics (STEM) disciplines and careers. We investigate how identities are negotiated as individuals navigate educational, professional, and community landscapes, as well as the historical legacy of the detrimental way that Western science has positioned Native culture. We conducted interviews with Native STEM professionals and we found that a common factor in their experience is the strength of their self-identity as Native people. Contradicting both mainstream beliefs that STEM expertise requires a Western sensibility and common attitudes in Native communities that pursuing a career in STEM is antithetical to Native cultural affiliation, it is the depth of their Native identity that gives interviewees a platform for success in science.