WHO declared COVID-19 infection as a pandemic since 2020. A rapid noninvasive examination is needed for screening and diagnostic. Exhaled Volatile Organic Compound (VOC) is a sample directly connected to the affected organ, which is the lung, and can be measured as an endogenous volatile marker resulted from oxidative stress. This study aims to analyze differences in VOC concentration in COVID-19 patients with pneumonia and without pneumonia. This Case Control Study used 93 confirmed case samples of COVID-19 and 42 healthy subject. Demographic and clinical data taken from anamnesis and/or medical records. VOC’s data of respiratory track are taken through the exhalation air in a bag and analyzed with breathanalyzer. Statistical analysis was conducted using Mann-Whitney test. In the analysis of confirmed samples of COVID-19 between pneumonia and without pneumonia, co components were found to affect the incidence of pneumonia in confirmed samples of COVID-19 (p=0.003). This conclusion is Components of CO in confirmed COVID-19 have a meaningful effect on an event of pneumonia.

Background/aim: The analysis of VOCs through respiration has been used for biomarker analysis for the detection of novel coronaviruses and has found mainly six VOCs by breath analysis by GC-IMS are ethanol, octane, acetone, cluster mixture of acetone/butanone and methanol. Previous research found exhaled methanol concentrations were lower in COVID-19 patients. The aim of this study was to analyze differences in VOC concentration in Covid-19 patients with healthy people. Methods: This Case Control study used 93 confirmed case samples of Covid-19 and 42 healthy people. Demographic and clinical data taken from anamnesis and/or medical records. VOC’s data of respiratory track are taken through the exhalation air in a bag and analyzed with breath analyzer. Statistical analysis was conducted using Mann-Whitney test. Results: VOC compound measured include CO2, C7H8, CH2O, NH4, TVOC, NO2, PM1.0, CO, NH3, and Acetone. Analysis between Covid-19 patients and healthy people showed significant differences in all VOC components CO2 (p=0,000), C7H8 (p=0,000), CH2O (p=0,000), NH4 (p=0,001), TVOC (p=0,000), NO2 (p=0,000), PM1.0 (p=0,000), CO (p=0,000), NH3 (P=0,000), Acetone (p=001). Logistic regression analysis was obtained no meaningful influence on each component of the VOC with covid/healthy people conditions of patients with components CO2 (p=1,000), C7H8 (p=1,000), CH2O (p=0,999), NH4 (p=1,000), TVOC (p=1,000), NO2 (p=1,000), PM1.0 (p=0,999), CO (p=0,999), NH3 (P=0,999), Acetone (p=1,000). Conclusion: There is a significant difference between the VOC results of confirmed COVID 19 patients and healthy people Keywords: breath analyzer, coronaviruses, COVID-19, healthy people, volatile organic component

Background: Adenocarcinoma is the most common Non-Small Cell Lung Cancer (NSCLC) in non-smokers in Indonesia. It often metastasizes in multiple sites. Metastasis is a negative predictor for prognosis in lung adenocarcinoma. In this covid pandemic era we present a case of a 30-years-old woman with adenocarcinoma and multiple-sites metastasis, and Coronavirus-19 Disease (COVID-19). Case: A 30-year-old woman came to our hospital with multiple complaints of hearing loss, visual loss, and occasional shortness of breath. The patient had a history of wild-type EGFR adenocarcinoma and has been treated with 4 cycles of gemcitabine. She also presented with a lump in her neck. Further examination revealed multiple metastasis tumours in her brain, right eye, neck, and spine. Pleural fluid examination also showed a malignant pleural effusion. Nasopharyngeal swab using reverse transcriptase-polymerase chain reaction (rt-PCR) method revealed that she also suffers from COVID-19 with positive swab result. Despite adequate treatment, she rapidly deteriorates and passed away in hospital. Discussion: Management in this patient is complex due to multiple complications and limitation of management given in COVID-19 isolation ward. She presented with multiple equally complicated metastasis, in which treatment priority should be carefully assessed. Despite treatment by multiple specialists, her problems still persist and proved to be fatal. Conclusion: Although metastasis is common in adenocarcinoma, multiple metastasis is uncommon, and this case highlights the need of careful management priority in such patients in COVID-19 pandemic setting. Keywords: Adenocarcinoma, Multiple Metastasis, Lung Cancer, COVID-19