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neurological complication was epilepsy (91%). Statistically significant associations were found between a) fibrous plaque of forehead with ipsilateral structural cerebral lesions or contralateral seizures (p<0.01) and b) shagreen patches (p<0.001) and angiofibromas of the face (p<0.001) with renal manifestations. Shagreen patch was associated with ipsilateral renal involvement. Conclusions:Fibrous plaque of forehead may be considered a cutaneous marker of ipsilateral central nervous system manifestations, Angiofibromas of the face and shagreen patches may be considered as markers of renal involvement.