BackgroundDepression in the workplace creates a significant burden on employees and employers in terms of lost productivity and related costs. myStrength provides a robust, holistic Web- and mobile-based solution empowering users to learn, practice, and implement a range of evidence-based psychological interventions.ObjectiveThe main aim of this study was to demonstrate improvement in depressive symptoms among employees at risk of depression through myStrength use.MethodsA 26-week, parallel-arm, pilot, randomized controlled trial was designed to assess the effectiveness of myStrength compared to a series of informational “Depression Tip/Fact of the Week” emails as the active control arm. Study participants (n=146) were commercially insured employees of a mid-sized financial software solutions firm. The primary outcome was self-reported change in depression score as best fit by a linear random effects model accounting for individual baseline symptoms.ResultsThe final sample consisted of 78 participants in the experimental arm, myStrength, and 68 participants in the active control arm. myStrength users demonstrated significantly steeper and more rapid reduction in depressive symptoms over time compared to the active control (P<.001), suggesting that the intervention generated improvement in behavioral health symptoms, even in a nonclinical sample.ConclusionsThis pilot study builds foundational support for the scalable deployment of myStrength as a complementary behavioral health offering to promote overall mental health and well-being in the workplace.

PURPOSE: Genetic counseling and testing (GC/T) for breast cancer–associated genetic mutations are important components in the appropriate management of newly diagnosed breast cancer. We initiated pathways to help appropriately select patients who meet criteria for GC/T referral (GC/T-R) across the Sarah Cannon Cancer Institute Network. This study evaluated physician pathway training as a means to improve access to GC/T-R. METHODS: In this retrospective, observational study, we collected data from 7 regions across 6 states, identifying 3,113 patients eligible for GC/T. Patients were divided into 3 defined cohorts: patients treated before implementation of pathways (n = 988), patients treated by non-pathway physicians after pathways were established (n = 1,094), and patients treated by pathway-trained physicians (n = 1,031). Pathways were established in March 2016. Nurse navigators documented eligible patients who were referred for GC/T within a care coordination software system. RESULTS: Eligible patients were referred for GC/T 71.77% of the time if treated on pathways and only 36.47% of the time if treated off pathways. On-pathway patients eligible for GC/T also received testing referral at a higher rate than pre-pathway patients (21.36%). CONCLUSION: After implementation of pathways and appropriate training of physicians on those pathways, GC/T-R among appropriate patients significantly improved. Pathway training represents a potential solution to improve GC/T-R among patients with breast cancer.

Background As with other complex therapies, treatment of AML varies among centers (ctrs) due to differences in patients (pts), infrastructure and care delivery models. Variation in ctrs practices, experience and resources may influence pt outcomes. Few studies have examined the association of ctr characteristics and survival in AML. Previous research offers conflicting results regarding outcomes of AML pts treated in National Cancer Institute Comprehensive Cancer Centers (NCICCC) versus community settings; neither study investigated ctr-level differences other than volume. We sought to compare AML outcomes in any of the HCA Healthcare (HCA) network of 131 community hospitals from 2011-18 with those reported in the Surveillance, Epidemiology, and End Results (SEER) database. We then examined pt, disease and center-related characteristics influencing outcomes in HCA hospitals. Methods We identified pts with AML (excluding APL) > 18 yrs treated between 10/31/11 and 10/31/18 in an HCA hospital (N = 4,882) and obtained pt level data from electronic medical records. A comparative population treated was developed from the most recent SEER database (2011-15; N = 19,349). We used coarsened exact matching to control for as many potential biases as possible. We compared mortality at 30, 90 and 120-days and overall survival curves between HCA and SEER . A Cox regression model was used to investigate differences in hazard rates among HCA facilities while simultaneously assessing the impact of patient characteristics and facility characteristics. Of the HCA patients, 1339 were treated in 6 hospitals that meet defined metrics of infrastructure, staffing, processes and volume as part of certification to participate in the Sarah Cannon Blood Cancer Network (SCBCN). Results Matching for age, gender and race, HCA pts were found to have significantly lower mortality than SEER at 30, 90 and 120 days (p<.001) as well as significantly better survival (p<0.001; fig.1). We next investigated how pt and facility characteristics interact to predict outcomes for HCA patients (table 1). Elevated White Count at diagnosis (HR=1.3), Charlson index (HR=1.1), older age (HR= 1.04), and receiving treatment at a hospital with larger bed count (HR=1.26) were associated with significantly worse survival. Commission on Cancer (COC) accreditation status, Socio-economic status (SES), distance to facility, and gender did not significantly impact risk. Being treated in the SCBCN (HR=0.68) and African American race (HR= 0.66) were associated with improved survival Conclusions Previous research utilizing registry data demonstrated better survival for pts with AML treated in higher volume centers but provides conflicting information about survival for pts treated in a NCICCC versus a community setting. Neither study examined center characteristics beyond NCI designation. This report examines a large pt cohort treated in community hospitals across the US. Pts treated in these hospitals had significantly better survival than a matched cohort from the SEER database. We validate the importance of age, acuity and Charlson index as adverse factors. Analysis of facility characteristics demonstrated that qualification as a member of SCBCN was associated with improved survival underscoring the importance of infrastructure, quality systems and volume in achieving improved outcomes. Disclosures Lemaistre: HCA: Employment. Chao:HCA: Employment. Cruz:1. Daiichi Sankyo advisory board: Membership on an entity's Board of Directors or advisory committees; Takeda: Consultancy, Speakers Bureau. Eghtedar:Verastem Oncology: Consultancy; Novartis: Consultancy, Honoraria, Speakers Bureau; Jazz: Consultancy, Honoraria, Speakers Bureau; Celgene: Honoraria, Speakers Bureau; Takeda: Honoraria, Speakers Bureau. Holder:Sarah Cannon: Employment. Malik:Kite Pharma: Honoraria. Rotta:Kadmon Corporation, LLC: Consultancy; Jazz: Speakers Bureau.