Protein folding problem obtained a practical solution recently, owing to advances in deep learning. There are classes of proteins though, such as antibodies, that are structurally unique, where the general solution still lacks. In particular, the prediction of the CDR-H3 loop, which is an instrumental part of an antibody in its antigen recognition abilities, remains a challenge. Antibody-specific deep learning frameworks were proposed to tackle this problem noting great progress, both on accuracy and speed fronts. Oftentimes though, the original networks produce physically implausible bond geometries that then need to undergo a time-consuming energy minimization process. Here we hypothesized that pre-training the network on a large, augmented set of models with correct physical geometries, rather than a small set of real antibody X-ray structures, would allow the network to learn better bond geometries. We show that fine-tuning such a pre-trained network on a task of shape prediction on real X-ray structures improves the number of correct peptide bond distances. We further demonstrate that pre-training allows the network to produce physically plausible shapes on an artificial set of CDR-H3s, showing the ability to generalize to the vast antibody sequence space. We hope that our strategy will benefit the development of deep learning antibody models that rapidly generate physically plausible geometries, without the burden of time-consuming energy minimization.

Introduction. In 1987, sport was known in the literature as an area representing a traditional male power, strength and violence. In 2020, women's sport became recognized as the mainstream, which only confirmed similar conclusions made over the past years. One of the challenges in the area of sport over the next years was women’s sport activation and reaching them through sponsorship communication. This has been facilitated, inter alia, by the development of women's sport and its marketing potential. The study aims to present the image of a woman in marketing communication based on sports motives. The selected aspects subjected to analysis will help to define the role of women in advertising sports communication and verify the declarations of the companies that achieve their goals using this level of communication. Another aim is to investigate whether the belief in the feminization of sports fandom and involvement of women in the fan culture finds confirmation in advertising.   Method. The author has analysed selected TV, cinema and internet advertising campaigns (audio-video format) containing sports accents. Communications of 1,270 films representing 254 brands was analysed. The analysis covered seven different areas: characters, image and product advertising, share of sports disciplines, sports accessories used, the woman’s attitude, an area of the sports involvement, and the values presented. Results. The analysis allowed to obtain an image of a woman being aware of her strength, who can derive great joy from sport. She believes that this is an important and popular area which has a beneficial effect on health and guarantees a shapely figure and great fun. She is a woman being aware of a number of values that come with sport, as she can see how much she benefits in the spiritual, physical and emotional dimensions. However, she feels her emotions much more often through the way to success and fighting for the position of a leader rather than cheerleading.

Artykuł stanowi podsumowanie badania „Rola komunikacji korporacyjnej” przeprowadzonego przez agencję Public Dialog przy współpracy z autorem artykułu w 2016 roku. Oprócz charakterystyki komunikacji korporacyjnej, jej celów i roli, jaką pełni w przedsiębiorstwach, pokazano stojące przed nią wyzwania i trendy. Skoncentrowano się również na znaczeniu interesariuszy oraz kluczowych obszarów wspierających komunikację. Opisano narzędzia komunikacji najistotniejsze z punktu widzenia komunikacji korporacyjnej, pomiary jej efektywności oraz kanały komunikacyjne, które mają i będą miały największe znaczenie w przyszłości.

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Sport is an attractive business platform for communication not only with customers, but also with all stakeholders. It can be observed not only in advertising communication of the producers operating on the broadly understood sports market, sponsors or companies using ambush marketing. It is also used in brand marketing by companies which, despite their lack of connotation with sport, willingly benefit from a number of sports attributes, values and connotations. The study aims to present the image of a man in marketing communication based on sports motives. The selected aspects subjected to analysis will help to define the role of a man in advertising sports communication and verify the declarations of the companies that pursue their goals using this level of communication. The author analysed selected advertising campaigns (audio-video format) containing sports accents. Communications of 1,270 advertisements representing 254 brands were analysed. The analysis covered six different areas: image and product advertising, share of sports disciplines, sports accessories, the man's attitude, an area of the sports involvement, and the valued presented. The analysis showed that the man presented in a sports advertisement is multidimensional, just as sport is. Traditional areas connotated with sport, such as competition and team support, are not the only ones to penetrate the advertising’s contents. While the former area is very common in general, this is one of the least frequently used sports motives. Much more often, sport appears as an element to build man’s identity, his inner strength, heroic spirit. The sport spirit and values underlying such an identity appears to be more important than most of the sport disciplines presented in advertisements. Exception to the rule is football, which continues to be the number one, regardless of whether it concerns the man’s image promoted by a male sports star or by an anonymous man.