The incidence of thyroid dysfunction in the area of central Bosnia with special reference to hyperthyroidism was being monitored. Considering that there were disagreements among earlier authors and even their contradictory results, the goal was to determine the percentage ratio between the thyroid hyperfunction and other dysfunctions and to identify the degree of correlation between thyroid hormones and the age structure of women. The study included 76 women aged 20 to 82 years with increased values of thyroid hormones and 49 women with reduced values of thyroid hormones. Thirty female patients with baseline thyroid hormone levels comprised a control group. Hyperthyroidism was observed in 60.8 % of women, with the highest percentage of getting ill in their fourth and fifth decade of life (64 %). The monitoring of TSH, FT4 and FT3 hormone values in thyroid dysfunction compared to women with thyroid gland hormone reference values by age groups showed that there was a statistically significant difference in the age group between 40 and 59 years (p < 0.05). For the age group of 60 years and older, there was no significant difference (p > 0.05). The TSH hormone value and the age of women are positively correlated and mutually dependent (p < 0.05). The observed reduction in the thyroid hormone values with an increase in women's age can be considered an adaptation of the organism to the reduced need for energy and represents an important metabolic parameter of the biological process of aging.

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Introduction: The influence and interactions of various genetic, hormonal, environmental and nutritional factors and risks for decreased bone mineral density in older age are not yet clear. The aim of this study was to examine relationship between reduced exposure to estrogen over a lifetime (early age at menopause, shorter period between menarche and menopause) and bone mineral density in older women. Methods: A total of 60 women, aged 60-75 years were included and assigned to osteoporosis group (n=30), or control group with normal bone mineral density or osteopenia (n=30). The values ​​of bone mineral density were obtained by dual energy X-ray absorptiometry (DXA) at the lumbar spine (L2-L4) and proximal femur. Results: Women with osteoporosis entered the menopause at a younger age (43.03±3.18 years) compared to women without osteoporosis (51.93± 2.30 years) and the difference was statistically significant, p=0.0001. In addition, women with osteoporosis had shorter timespan between menarche and menopause (28.33±3.31 years), compared to women without osteoporosis (38.43±2.48 years), which was statistically significant, p=0.0001. Conclusion: Reduced exposure to estrogen over a lifetime because of early menopause, and shorter timespan between menarche and menopause may be associated with decreased bone mineral density and osteoporosis in postmenopausal women.

Thiamazole inhibits the thyroid hormone synthesis and does not inactivate the existing thyroxine and triiodothyronine that circulate in the blood. In this paper Thiamazole electrochemical behavior was monitored by cyclic voltammetry on glassy carbon (GC) electrode in the absence and presence of sodium pertechnetate (99mTc). The influence of different Thiamazole concentrations without and in the presence of radiopharmaceutical 99mTc, the effect of the number of scan cycles, and the effect of 99mTc activity on the appearance of cyclic voltammograms were examined. The results show that there is an observed increase in the reduction peak current with an increase of Thiamazole concentration. It was found that the concentration of the tested drug had a significant effect on its redox characteristics. The results obtained show that the application of different concentrations of sodium pertechnetate exhibits the inhibitory properties of the used radiopharmaceutical on the drug in the treatment of thyroid gland disease.