published from January 1st to 27th of December 2020. Two independent reviewers evaluated studies using the STROBE statement in combination with the CERQual quality assessment of findings. Total 1387 articles were screened and a final 24 studies evaluated (220 1st/2nd trimesters COVID-19 pregnant women). 132/220 (60%) were symptomatic, most commonly with fever (86/220=39%) or cough (73/220=33%). Minority of studies reported complications, notably preeclampsia (2/15 patients-13%). 3 cases of maternal death were reported. Majority of neonates had unreported status concerning the outcome of pregnancy. Neonatal death occurred in 17 cases (including one chemical pregnancy, 5 miscarriages, 2 IUFD, 6 stillbirths and 3 abortions) Majority of reported mothers who contracted COVID-19 during 1st/2nd trimesters are yet to complete their pregnancy. Usually, mothers are discharged from the hospital without any serious complications, however, placental inflammation/fibrin deposition and neonatal death has been reported in a number of cases.

BackgroundBronchopulmonary dysplasia (BPD) is a chronic lung disease that mainly affects premature newborns. Many different factors, increasingly genetic, are involved in the pathogenesis of BPD. Fibronectin is a multi-domain glycoprotein present in nearly all vertebrate tissues and organs. Material and methodsThe study included 108 infants born between 24 and 32 weeks of gestation. BPD was diagnosed based on the National Institutes of Health Consensus definition. The 5 FN1 gene polymorphisms assessed in the study were the following: rs3796123; rs1968510; rs10202709; rs6725958; and rs35343655. ResultsBPD developed in 30 (38.5%) out of the 108 preterm infants. Incidence of BPD was higher in infants with lower APGAR scores, low gestational age, and low birthweight. Investigation did not confirm any significant prevelance for BPD development in any genotypes and alleles of FN1. ConclusionFurther studies should be performed to confirm the role of genetic factors in etiology and pathogenesis of BPD.

Background Bronchopulmonary dysplasia (BPD) is a chronic lung disease that mainly affects premature newborns. Many different factors, increasingly genetic, are involved in the pathogenesis of BPD. Fibronectin is a multi-domain glycoprotein present in nearly all vertebrate tissues and organs. Material and methods The study included 108 infants born between 24 and 32 weeks of gestation. BPD was diagnosed based on the National Institutes of Health Consensus definition. The 5 FN1 gene polymorphisms assessed in the study were the following: rs3796123; rs1968510; rs10202709; rs6725958; and rs35343655.Results BPD developed in 30 (38.5%) out of the 108 preterm infants. Incidence of BPD was higher in infants with lower APGAR scores, low gestational age, and low birthweight. Investigation did not confirm any significant prevelance for BPD development in any genotypes and alleles of FN1. Conclusion Further studies should be performed to confirm the role of genetic factors in etiology and pathogenesis of BPD.

BackgroundBronchopulmonary dysplasia (BPD) is a chronic lung disease that mainly affects premature newborns. Many different factors, increasingly genetic, are involved in the pathogenesis of BPD. Fibronectin is a multi-domain glycoprotein present in nearly all vertebrate tissues and organs. Material and methodsThe study included 108 infants born between 24 and 32 weeks of gestation. BPD was diagnosed based on the National Institutes of Health Consensus de nition. The 5 FN1 gene polymorphisms assessed in the study were the following: rs3796123; rs1968510; rs10202709; rs6725958; and rs35343655. ResultsBPD developed in 30 (38.5%) out of the 108 preterm infants. Incidence of BPD was higher in infants with lower APGAR scores, low gestational age, and low birthweight. Investigation did not con rm any signi cant prevelance for BPD development in any genotypes and alleles of FN1. ConclusionFurther studies should be performed to con rm the role of genetic factors in etiology and pathogenesis of BPD.