Image-guided high-intensity focused ultrasound (HIFU) is an innovative therapeutic technology, permitting extracorporeal or endocavitary delivery of targeted thermal ablation while minimizing injury to the surrounding structures. While ultrasound-guided HIFU was the original image-guided system, MR-guided HIFU has many inherent advantages, including superior depiction of anatomic detail and superb real-time thermometry during thermoablation sessions, and it has recently demonstrated promising results in the treatment of both benign and malignant tumors. HIFU has been employed in the management of prostate cancer, hepatocellular carcinoma, uterine leiomyomas, and breast tumors, and has been associated with success in limited studies for palliative pain management in pancreatic cancer and bone tumors. Nonthermal HIFU bioeffects, including immune system modulation and targeted drug/gene therapy, are currently being explored in the preclinical realm, with an emphasis on leveraging these therapeutic effects in the care of the oncology patient. Although still in its early stages, the wide spectrum of therapeutic capabilities of HIFU offers great potential in the field of image-guided oncologic therapy.

Intracranial aneurysms affect 2-4% of the population. 1-3 Recent advancements in intracranial vessel wall (IVW) MRI have improved our ability to characterize intracranial vascular diseases 4-6 including aneurysms, particularly with the use of 3D Variable Refocusing Flip Angle (VRFA) techniques. 7,8 Vasa vasorum, not normally present in intracranial arteries, is thought to develop in larger aneurysms, which may leak, resulting in inflammation, aneurysm enlargement, and wall thinning. It has been suggested that enhancement of the vessel wall is due to the presence of vasa vasorum or associated inflammation, 9 and prior studies have shown that enhancement is readily detectable on IVW, and seen more frequently in ruptured or vulnerable aneurysms. 10-15 Wall thinning may also be an important factor in aneurysm rupture, 16 and IVW can qualitatively evaluate aneurysm wall thickness. 17,18 Aneurysm rupture is associated with devastating consequences, 19-21 but both endovascular and surgical treatments pose their own risks 22-24-therefore optimized patient selection is critical. Treatment algorithms for unruptured aneurysms have traditionally focused on size, 25 however, natural history studies of unruptured aneurysms have described a 5-year risk of rupture of 4.5% for aneurysms smaller than 10 mm, as well as reporting rupture in

The use of the Vertiflex® interspinous spacer is a recent minimal invasive procedure useful in the treatment of lumbar spinal stenosis (LSS). It is used mostly by interventional pain physicians who can also perform the minimally invasive lumbar decompression (MILD procedure). Previously when a patient had clinical symptomatic neurogenic claudication (NC) and radiologic findings of lumbar stenosis and had failed conservative treatment, the options were decompressive laminectomy, laminectomy with pedicle fixation at one or more levels or laminotomy combined with interlaminar stabilization (Coflex® implant). These procedures were performed by neurosurgeons and orthopedic spine surgeons. However, the majority of patients with LSS are elderly and have multiple comorbidities that can make open spinal surgery, even when limited to one level, an anesthesia risk as well as vulnerable to the risk associated with hospitalization and recovery after spine surgery. The minimally invasive approaches to interspinous stabilization make it possible to treat localized symptomatic stenosis in a broader group of patients that do not want or cannot, have general anesthesia or extensive lumbar surgery, especially in the prone position. This article examines the use of the Vertiflex® implant in an elderly population with significant comorbidities that underwent successful outpatient implantation at one or two levels. In addition, it serves to familiarize spine surgeons about the possibility of using more minimal approaches to treat LSS.

In this case, an 80-year-old active patient developed an acute osteoporotic fracture after a fall at L1 above a previous interlaminar implant at L4-5 for stenosis with neurogenic claudication. Radiologic studies found both intra-discal and intra-vertebral vacuum clefts that are highly correlated with instability and progressive kyphosis. Long-term experience with kyphoplasty has shown that acute and subacute fractures can often be re-expanded; however, over three months to one year, the correction is frequently lost and the vertebral height continues to decrease leading to increased risk of both continued deformity and especially adjacent level fractures. The use of newly available titanium intra-vertebral implants combined with bone cement restores and maintains vertebral height and correction of deformities. Long-term studies also demonstrate a reduced risk of adjacent level fractures compared to balloon kyphoplasty. Using vertebral body implants that remain in place within the fractured vertebral body the initial height correction can be better maintained leading to less adjacent level fractures.