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Since the COVID-19 outbreak began, there has been an urgent need for a safe and effective vaccine to end this global pandemic. One such vaccine is the Ad5-nCoV, developed by CanSino Biologics Inc. This review aims to examine all animal and human trials conducted for this vaccine candidate. Search terms such as “Ad5-nCoV”, “recombinant adenovirus”, “COVID-19”, and “vaccine”, were used in varying combinations in the PubMed database to find published trial reports. It was concluded that Ad5-nCoV can induce a strong immune response in mice and ferret models and offer them protection against the inoculation of SARS-CoV-2. It also has a strong safety profile in human and can induce an adequate immune response in terms of RBD-specific antibodies and T cell responses, while neutralizing antibody response and seroconversion was mediocre. The publish trial reports support the further testing of this vaccine candidate and it is preparing to enter phase 3 clinical trials.

Neurogenesis is vital in the preservation of cognition. Previous studies have reported antioxidant vitamins as a key regulatory factor in neurogenesis. However, current research investigating their role is inconclusive due to the limited number of studies that have been conducted and conflicting results. This review evaluates the scientific evidence behind the potential roles of antioxidant vitamins in neurogenesis. Observations concerned with the mechanistic and functional aspects of how antioxidant vitamins modulate neurogenesis are both assessed. Vitamin A is evidently involved in cell cycle regulation and cell proliferation; vitamin C reportedly promotes neural differentiation and maturation while inhibiting neurite outgrowth; vitamin E is identified to inhibit cell proliferation while improving cell viability. Varying antioxidant vitamin concentrations have been implicated in facilitating cognition in terms of attention, memory, language, and executive function. Moreover, this review suggests a threshold antioxidant vitamin concentration that should be maintained to promote optimal levels of adult neurogenesis.

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