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Cloud Computing is the latest advancement used by the relationship to manage gigantic proportion of data. This paper will explain Cloud Computing, its technologies, advantages, challenges and its application use. The affiliations could have their own cloud server ranch or in like manner can limit with various data expert centres who gives the workplace of disseminated figuring. The data is split between various servers and subsequently can be gotten to starting there. It helps with extending the viability of the business affiliation. There is no direct involvement of the user to manage the data present in the cloud computing technology. The clouds can be big or small or private or public based upon the data requirement of the business and the quantity and quality of the data. The paper will also explain the implementation process of cloud computing and various types of clouds available in the market.

The second most prevalent cause of years of disability worldwide is migraine, a neurological condition that causes a persistent headache that is lifelong. This condition affects more than a billion people globally. Its widespread prevalence and concomitant impairment have several adverse effects. Migraines are brought on by numerous behavioural, ecological, and genetic factors. There are various types of migraines, of which migraine without aura is the most common. The objective of this article is to determine the causes of migraine headaches, review the appropriate diagnosis of migraine, and describe the migraine headache management alternatives that are available. Various treatments for migraine are available on the market. Among the many types of headaches, migraines are neurological in nature and are inherited in some people. It has four phases: prodromal phase, aura, attack phase, and postdrome phase. Stress, anxiety, changes in the female endocrine system, bright lights, loud noises, foul odour, excessive or insufficient sleep, changes in the environment or the climate, flashes of light or intense lighting, overexertion, missing meals, drinking alcohol and smoking, quitting caffeine, and taking too many migraine drugs are some of the triggering factors for migraine. Diagnosis of migraine mainly relies on a good history. Appropriate prevention can be done for specific indications. Treatment mainly revolves around medications like analgesics, triptans, ergot derivatives, and newly derived biologics. Lifestyle modifications are also essential as many daily life factors contribute to migraine. Migraine can be well-managed if sufficient attention and care are given along with proper medications and guidance. The patient should not ignore symptoms and report to the physician at the earliest so that correct management can be done.

Distal enhancers play critical roles in sustaining oncogenic gene expression programs. We identify aberrant enhancer-like activation of GGAA tandem repeats as a characteristic feature of B-cell acute lymphoblastic leukemia (B-ALL) with genetic defects of the ETV6 transcriptional repressor, including ETV6-RUNX1+ and ETV6-null B-ALL. We show that GGAA repeat enhancers are direct activators of previously identified ETV6-RUNX1+/-like B-ALL “signature” genes, including the likely leukemogenic driver EPOR. When restored to ETV6-deficient B-ALL cells, ETV6 directly binds to GGAA repeat enhancers, represses their acetylation, downregulates adjacent genes, and inhibits B-ALL growth. In ETV6-deficient B-ALL cells, we find that the ETS transcription factor ERG directly binds to GGAA microsatellite enhancers and is required for sustained activation of repeat enhancer-activated genes. Together, our findings reveal an epigenetic gatekeeper function of the ETV6 tumor suppressor gene and establish microsatellite enhancers as a key mechanism underlying the unique gene expression program of ETV6-RUNX1+/-like B-ALL.

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