Sarcoptes scabiei infestation was diagnosed in four freshly dead and three net-captured gazelle while ranging freely. The captured animals presented with an alopecic pruritic skin disease with signs of crusted skin lesions, numerous small nodules which first appeared on the lips or nostrils and then it also extended towards the eyelids, around the ears, and, in some cases, over entire face, neck, trunk, and legs. Skin over the affected area gradually became bald, thick and hard, being dry and doughy to the touch, and serous fluid or sometimes blood oozes from the lesions which had a severe malodor. Skin scrapings confirmed the presence of the mite S. scabiei. Histopathology of lesions demonstrated marked acanthosis, hyperkeratosis, and parakeratosis. Microscopical examination also revealed all stages of S. scabiei, which were located mainly in the stratum corneum and also in the stratum granulosum. During the capture and sampling of the animals, four persons ranging in age from 25 to 62 years were exposed to scabies. Two relatives of one of them have been also affected by familiar contact. Clinical signs appeared within 9 days of exposure. They developed several pruretic erythematous papules with intense itching.