Background: Most common cancer in women that is 32 % of all newly diagnosed cancers is breast cancer. Breast cancer develops when cells of your breast multiply and divide uncontrollably, resulting in a lump of tissue known as a tumor. Screening type of mammography has played a key role in reducing breast cancer mortality. Aim: To evaluate role of three diagnostic modalities in the breast cancer. Methods: The data bases PubMed and other search engines were searched with the key words: breast cancer, mammography, ultrasound, MRI, sensitivity, specificity, from 1999 to 2020. For inclusion and exclusion of studies we screened the most relevant and irrelevant outcomes. Studies having information of breast cancer, mammography, ultrasound, MRI, sensitivity, specificity was included. Meta-analysis were excluded. Results: In total 39 studies with breast cancer the overall mean sensitivity of ultrasound, mammography and MRI were 76.81, 74 and 88.18 respectively. Overall mean specificity of ultrasound, mammography and MRI 79.65, 87 and 75.17 respectively. SD of Sensitivity and Specificity of MRI is 10.57 and 16.27. SD of Sensitivity and Specificity of mammography is 20.92 and 16.43. SD of Sensitivity and Specificity of ultrasound is 23.71 and 20.05. Conclusions: MRI, because of its limitations cannot be used routinely for diagnosing breast cancer. Mammography is readily available screening tool for breast cancer however it has low sensitivity for diagnosis of breast cancer and requires complimentary imaging. Ultrasound can be used as baseline modality as it saves time and safe in all conditions. Keywords: Breast Cancer, Mammography, Ultrasound, MRI, Sensitivity, Specificity