Background: Glucagon-like peptide 1 agonists differ in chemical structure, duration of action and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. Methods: We randomly assigned patients with type 2 diabetes and cardiovascular disease to the addition of once-weekly subcutaneous injection of albiglutide (30 mg to 50 mg) or matching placebo to standard care. We hypothesized that albiglutide would be noninferior to placebo for the primary outcome of first occurrence of cardiovascular death, myocardial infarction, or stroke. If noninferiority was confirmed by an upper limit of the 95% confidence interval for the hazard ratio of less than 1.30, closed-testing for superiority was prespecified. Findings: Overall, 9463 participants were followed for a median of 1.6 years. The primary composite outcome occurred in 338 of 4731 patients (7.1%; 4.6 events per 100 person-years) in the albiglutide group and in 428 of 4732 patients (9.0%; 5.9 events per 100 person-years) in the placebo group (hazard ratio, 0.78; 95% confidence interval [CI ], 0.68 to 0.90), indicating that albiglutide, was superior to placebo (P<0.0001 for noninferiority, P=0.0006 for superiority). The incidence of acute pancreatitis (albiglutide 10 patients and placebo 7 patients), pancreatic cancer (6 and 5), medullary thyroid carcinoma (0 and 0), and other serious adverse events did not differ significantly between the two groups. Interpretation: In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. (Funded by GlaxoSmithKline; Harmony Outcomes ClinicalTrials.gov number, NCT02465515.) noninferiority; P = 0.06 for superiority). There seems to be variation in the results of existing trials with GLP-1 receptor agonists, which if correct, might reflect drug structure or duration of action, patients studied, duration of follow-up or other factors.
The Javalambre-Physics of the Accelerating Universe Astrophysical Survey (J-PAS) will scan thousands of square degrees of the northern sky with a unique set of 56 filters using the dedicated 2.55m JST at the Javalambre Astrophysical Observatory. Prior to the installation of the main camera (4.2 deg 2 field-of-view with 1.2 Gpixels), the JST was equipped with the JPAS-Pathfinder, a one CCD camera with a 0.3 deg 2 field-of-view and plate scale of 0.23 arcsec pixel −1 . To demonstrate the scientific potential of J-PAS, the JPAS-Pathfinder camera was used to perform miniJPAS, a ∼1 deg 2 survey of the AEGIS field (along the Extended Groth Strip). The field was observed with the 56 J-PAS filters, which include 54 narrow band (NB, FWHM ∼ 145 Å) and two broader filters extending to the UV and the near-infrared, complemented by the u, g, r, i SDSS broad band (BB) filters. In this miniJPAS survey overview paper, we present the miniJPAS data set (images and catalogs), as we highlight key aspects and applications of these unique spectro-photometric data and describe how to access the public data products. The data parameters reach depths of mag AB 22 − 23.5 in the 54 narrow band filters and up to 24 in the broader filters (5σ in a 3 aperture). The miniJPAS primary catalog contains more than 64, 000 sources detected in the r band and with matched photometry in all other bands. This catalog is 99% complete at r = 23.6 (r = 22.7) mag for point-like (extended) sources. We show that our photometric redshifts have an accuracy better than 1% for all sources up to r = 22.5, and a precision of ≤ 0.3% for a subset consisting of about half of the sample. On this basis, we outline several scientific applications of our data, including the study of spatially-resolved stellar populations of nearby galaxies, the analysis of the large scale structure up to z ∼ 0.9, and the detection of large numbers of clusters and groups. Sub-percent redshift precision can also be reached for quasars, allowing for the study of the large-scale structure to be pushed to z > 2. The miniJPAS survey demonstrates the capability of the J-PAS filter system to accurately characterize a broad variety of sources and paves the way for the upcoming arrival of J-PAS, which will multiply this data by three orders of magnitude. For reference, the miniJPAS data and associated value added catalogs are publicly available http://archive.cefca.es/catalogues/minijpas-pdr201912.
The evolution of the X-ray emitting gas mass fraction (fgas) in massive galaxy clusters can be used as an independent cosmological tool to probe the expansion history of the Universe. Its use, however, depends upon a crucial quantity, i.e., the depletion factor γ, which corresponds to the ratio by which fgas is depleted with respect to the universal baryonic mean. This quantity is not directly observed and hydrodynamical simulations performed in a specific cosmological model (e.g., a flat ΛCDM cosmology) have been used to calibrate it. In this work, we obtain for the first time self-consistent observational constraints on the gas depletion factor combining 40 X-ray emitting gas mass fraction measurements and luminosity distance measurements from type Ia supernovae. Using Gaussian Processes to reconstruct a possible redshift evolution of γ, we find no evidence for such evolution, which confirms the current results from hydrodynamical simulations. Moreover, our constraints on γ can be seen as a data prior for cosmological analyses on different cosmological models. The current measurements are systematic limited, so future improvements will depend heavily on a better mass calibration of galaxy clusters and their measured density profiles. 95.36.+x, 98.80.Es
Perturbative quantities, such as the growth rate (f ) and index (γ), are powerful tools to distinguish different dark energy models or modified gravity theories even if they produce the same cosmic expansion history. In this work, without any assumption about the dynamics of the Universe, we apply a non-parametric method to current measurements of the expansion rate H(z) from cosmic chronometers and high-z quasar data and reconstruct the growth factor and rate of linearised density perturbations in the non-relativistic matter component. Assuming realistic values for the matter density parameter Ωm0, as provided by current CMB experiments, we also reconstruct the evolution of the growth index γ with redshift. We show that the reconstruction of current H(z) data constrains the growth index to γ = 0.56 ± 0.12 (2σ) at z = 0.09, which is in full agreement with the prediction of the ΛCDM model and some of its extensions.PACS numbers: 95.36.+x, 98.80.Es
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