In Spain, a large number of adolescents aged over 14 years have at some time consumed a psychoactive substance such as alcohol (79%), tobacco (38.4%), prescribed or non-prescribed sedatives (16%), cannabis (29%), cocaine (3.5%), ecstasy (0.9%), hallucinogens (1.2%), heroin (0.6%), ketamine, spice, or similar (4%). Three in ten students have reported drug use or polydrug use in the last month, with 40.3% consuming one substance, 16.2% consuming two substances, 12.3% consuming three substances, and 2.6% consuming four or more substances (Observatorio Español de la Droga y las Toxicomanías, 2016). These figures highlight the need to analyze this phenomenon for two main reasons. First, substance use increases in adolescence (Negriff & Trickett, 2012), particularly middle adolescence (Hartz et al., 2012). Second, this use can have a neurological impact during this stage of development (Koskinen et al.
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