Bioisi MassSpec FacilityRationale: Fucus vesiculosus has been described with potential to develop functional foods containing bioactive compounds against various diseases. However, more studies are needed to better understand its functioning and its previously reported bioactivities, mainly at the molecular level.Methods: An untargeted metabolomic study was performed to analyse HepG2 cells exposed to F. vesiculosus aqueous extract, rich in phlorotannins and peptides, during 24 h. This study was carried out using liquid chromatography combined with highresolution tandem mass spectrometry.Results: This metabolomic study showed significant changes in HepG2 metabolites in the presence of the extract, standing out being the increased intensity of various fatty acid amides (oleamide, (Z)-eicos-11-enamide, linoleamide, palmitamide, dodecanamide and stearamide). This group of metabolites is reported in the literature with anticancer and hypocholesterolemic activity, bioactivities also described for F. vesiculosus. The extract induced, likewise, the expression of glutathione indicating its antioxidant effect.Conclusions: This study demonstrated the potential of the compounds present in the F. vesiculosus aqueous extract for the development of natural drugs, nutraceuticals or dietary supplements, justified at the molecular level by changes in cell metabolites related to anticancer and hypocholesterolemic activity. The results here described, using an untargeted metabolomic approach, may contribute to a better understanding of algal behaviour, when used as food, in health-promoting effects.

The gilthead seabream is one of the most valuable species in the Mediterranean basin both for fisheries and aquaculture. Marine fish, such as gilthead seabream, are a source of n3 polyunsaturated fatty acids, highly appreciated for human food owing to their benefits on the cardiovascular and immune systems. The aim of the present study was to estimate heritability for fatty acid (FA) profile in fillet gilthead seabream to be considered as a strategy of a selective breeding program. Total of 399 fish, from a broodstock Mediterranean Sea, were analysed for growth, flesh composition and FA profile. Heritabilities for growth traits, and flesh composition (fat, protein, and moisture content) were medium. Heritability was moderate for 14:0, 16:0 and 18:1n9 and for sum of monounsaturated FA and n6/n3 ratio, and it was low for 20:1n11 and 22:6n3 and the ratio unsaturated/saturated FA. Breeding programs in gilthead seabream usually include growth as the first criterion in the selection process of the fish. However, other quality traits, such as fillet fat content and its fatty acids profile should be considered, since they are very important traits for the consumer, from a nutritional point of view and the benefits for the health.

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Water drift emitted from cooling towers is objectionable for several reasons, mainly due to human health hazards. Generation and control of drift depends mostly on the drift eliminator, a device installed in mechanical cooling towers to prevent the escape of droplets (drift). These eliminators induce a rapid alternation of direction changes, and then the droplets cannot follow the path lines of the airflow within the channels of the eliminator and impact on the plates of it, falling back to the cooling tower ground. This paper focuses on the numerical study of a type of drift eliminator, validated by experimental tests. Three main aspects are considered: the water film formed on the plates of drift eliminators, the size of water droplets detached from this film and the condition of the detachment of these droplets. Good agreement is obtained between numerical and experimental results. The study shows that the behavior of water droplets is very influenced by the air velocity inside the cooling tower.

Water droplets emitted from cooling towers must be prevented for several reasons, human health hazards are the most important ones. The generation and control of these droplets are the main tasks for drift eliminators: devices installed inside mechanical draft cooling towers useful to prevent water droplets, originated by the crossflow between air and water inside the tower, from being released into the environment. This is the phenomenon called 'drift'. In this paper, the operating conditions of a type of drift eliminator placed in a cooling tower are studied. This work is focused on the numerical and experimental characterization of the multiphase flow taking place when water droplets, drifted by the airstream, impact on the water film formed over the drift eliminators plates. The problem of these drop impacts has been studied throughout an experimental installation and a numerical model has been developed throughout the ANSYS software and several VOF multiphase flow simulations have been carried out showing a good agreement with experimental data.