Infant MRI brain soft tissue segmentation become more difficult task compare with adult MRI brain tissue segmentation, due to Infant’s brain have a very low Signal to noise ratio among the white matter_WM and the gray matter _GM. Due the fast improvement of the overall brain at this time , the overall shape and appearance of the brain differs significantly. Manual segmentation of anomalous tissues is time-consuming and unpleasant. Essential Feature extraction in traditional machine algorithm is based on experts, required prior knowledge and also system sensitivity has change. Recently, bio-medical image segmentation based on deep learning has presented significant potential in becoming an important element of the clinical assessment process. Inspired by the mentioned objective, we introduce a methodology for analysing infant image in order to appropriately segment tissue of infant MRI images. In this paper, we integrated random forest classifier along with deep convolutional neural networks (CNN) for segmentation of infants MRI of Iseg 2017 dataset. We segmented infants MRI brain images into such as WM- white matter, GM-gray matter and CSF-cerebrospinal fluid tissues, the obtained result show that the recommended integrated CNN-RF method outperforms and archives a superior DSC-Dice similarity coefficient, MHD-Modified Hausdorff distance and ASD-Average surface distance for respective segmented tissue of infants brain MRI.