No abstract

Iron homeostasis is an interplay of numerous proteins which helps in regulating various pathways of iron recycling, absorption and excretion. Hepcidin is an important protein which plays a crucial role in regulating iron metabolism through its iron sensing and signaling pathway. Ferroportin normally transports iron in the circulation in case of need transcription of hepcidin in cases of excess iron negatively regulates the ferroportin activity by causing destruction of it. Nevertheless, hepcidin level increases in various physiological and pathological conditions as inflammation, chronic infection, hemochromatosis etc. Thus further knowledge of this pathway will help in better understanding of iron homeostasis in various conditions and help in development of therapeutic drugs.