Use of plant extracts in the treatment of several ailments is a science known to the mankind since time immemorial. Yet, its popularity is limited owing to the lack of recorded experimental evidence to determine their potential health benefits. C. roseus is a traditional medicinal plant with over 100 identified alkaloids and several other phytochemicals known for various health promoting activities. The aim of the present study was to evaluate C. roseus aqueous extracts' wound healing potential using incision, excision, and dead space wound models on healthy male albino rats. To assess this, the tissue breaking strength for incision wound model, percent epithelialization and period to complete epithelialization for excision wound model and granuloma break strength, dry weight, and hydroxyproline content for dead space wound model were evaluated after the treatment of the extract in comparison with the standard drug sucralfate. The results obtained demonstrated that the treatment of extract on the wound significantly enhanced tissue breaking strength and reduced the time required for complete epithelialization and was on par with that of the standard drug sucralfate. In the incision wound model, an elevated breaking strength was observed compared to that of the control group. Further, in the dead space wound model, the granuloma dry weight and breaking strength were remarkably elevated along with a concomitant increase in the hydroxyproline content suggesting the enhanced rate of wound contraction rate, collagen synthesis and lowered healing period. In conclusion, the present study demonstrates that C. roseus is effective in wound healing, as shown in the three wound models and thus, further studies to formulate this into a commercial product should be carried out.

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Epilepsy is one of the challenging medical conditions affecting neonates, children and elderly. It has affected 1710 to 9780/million  populations  within India. Although  the report of this condition  dates to the prehistoric era, drugs for its treatment are not 100% effective and more often lead to toxic effects. Therefore, a potent drug or a drug adjunct is the need-of-the-hour for providing effective control for this neurological condition. The aim of the present study is to evaluate lacidipine,  a  calcium  channel  blocker  as  a  protective  agent  in  seizures  induced  by  standard  models  of  epilepsy,  namely maximal electroshock  seizure model (MES) and Pentylenetetrazole  (PTZ). Standard methods for the induction of seizures such as MES and PTZ were performed on male Wistar albino mice. The mice were then treated with vehicle/standard drug (sodium valproate)/ lacidipine. Further, the standard parameters of recovery duration were evaluated. The study revealed that lacidipine at a dose of 3mg/kg body weight significantly reduced the duration of hind limb tonic extension and postictal depression in MES. PTZ-induced seizures showed significantly reduced mean duration of hind limb tonic flexion, hind limb tonic extension, clonus and postictal depression. The findings from the present study suggest that lacidipine has potent anticonvulsant ability in better protection against MES-induced seizures over that of the PTZ-induced one.