Age and sex 70 years old female patient. Previous history no preleukemia, no previous malignancy, no inborn condition of note. Organomegaly no hepatomegaly, no splenomegaly, no enlarged lymph nodes, no central nervous system involvement Blood WBC: 170 x 10 9 /l HB: 11.6g/dl Platelets: 134 x 10 9 /l Blasts: 95% Bone marrow: Hyper cellular and replaced by blasts (>90%) having increased nucleo-cytoplasmic ratio with 2 to 3 prominent nucleoli and cytoplasmic granules with strong positivity for myeloperoxidase. Cyto-Pathology Classification Phenotype AML M2 Immunophenotype MPO (Strong) Rearranged Ig Tcr Not performed Pathology Increased nucleo-cytoplasmic ratio with 2 to 3 prominent nucleoli and cytoplasmic granules. Diagnosis AML-M2 Survival Date of diagnosis 08-2012 Treatment Hydroxyurea. Complete remission: no Treatment related death: no Status Dead Last follow up 09-2012 Survival 1 month Karyotype Sample Bone marrow aspirate. Culture time Overnight and 24 hours without stimulating agents. Banding GTG Results GTG banding revealed a modal number of 47 with a ring chromosome. Screening of 30 metaphases and analysis of 15 karyotypes confirmed the ring Ring Chromosome 8: a case report