A doença de Krabbe é uma doença neurodegenerativa autossômica recessiva ocorrida por uma mutação do cromossomo 14q31.3. Diante disto, o objetivo deste trabalho foi descrever um caso de um paciente com Doença de Krabbes submetido a um tratamento multiprofissional. Até os 4 meses a criança apresentou seu desenvolvimento motor normal e logo após apareceu os primeiros sintomas. Aos 8 meses recebeu o diagnóstico e permaneceu até os 5 anos e 2 meses em atendimento domiciliar com acompanhamento de equipe Multiprofissional. Durante esse período apresentou-se estável, sem complicações e histórico de internações, ressaltando a relevância desse acompanhamento na sobrevida desses pacientes.

Introduction: the Aicardi syndrome (SA) is characterized as a rare syndrome identified in the presence of three classic characteristics: corpus callosum agenesis, chorioretinal lacunaeand infantile spasms. Description: data collection involved information reported by the mother and the accompanying physiotherapist describing the patient's clinical history andmajor complications according to clinical evolution, treatment, and therapeutic response. At two months of age, the child presented a delayed neuropsychomotor development and infantile spasms.However,the diagnosis of the syndrome was only performed at six months of life, involving brain magnetic resonance imaging where corneal body agenesis was observed. A multidisciplinary treatment was assembledwith a neuropediatrician, a physiotherapist, a psychologist, a nutritionistand a speech therapist, besides drug treatment with baclofen and phenobarbital. Discussion: through the established treatment, the child displayedmotor gain, cervical control, improvement of the respiratory condition, and no need forhospital admissions;these outcomescharacterizea good clinical evolution associated with the physiotherapeutic intervention focused on prevention and minimization of respiratory alterationsthatare frequently associated with morbidity and mortality in these cases. The results obtained point out the fundamental role of multidisciplinary intervention in coping with this condition.