Most of the patients with chronic diseases use many drugs are known as polypharmacotherapy. The latter being individuals who have a higher chance of suffering harmful effects of drug interactions, which did not fail to be different with patients of Physiotherapy School Clinic at Sorocaba city. The aim of this study was to investigate the evidence of the prescriptions of patients at the Clinical School of Physiotherapy. The prescriptions of patients in physiotherapy treatment, in the Neurology and Orthopedics areas, were analyzed. The results were obtained from a broad range of drugs currently used in patients presenting with from 1 to 14 drug interactions with other drugs. The most commonly used drugs were in cardiology, with a high prevalence of losartan and hydrochlorothiazide associations, present in 28.57% of the analyzed prescriptions. Hypertension, in conjunction with diabetes, causes a worsening of health and increases of drugs to be used in these patients. It is concluded that the primary interactions presented on the requirements of patients Clinical Physiotherapy School, at Sorocaba city, occurred among antihypertensive classes, nonsteroidal anti-inflammatory steroids, and hypoglycemic, confirming the need for the pharmacist to order the rational use of drugs