All patients undergoing general anaesthetic are at risk of acid aspiration, particularly in emergency situations when they have not been starved preoperatively. To minimise the risk of acid aspiration, anaesthetists and anaesthetic nurses employ Rapid Sequence Induction of anaesthesia, cricoid pressure and endotracheal intubation. Knowledge of airway anatomy, airway management techniques, anaesthetic agents, muscle relaxant drugs, and Sellick's Manoeuvre help the anaesthetic nurse ensure the safety of the high risk patient.