The effects of cremophor EL in the anaesthetized dogThe effects of cremophor EL were studied in 13 in PCWP, per cent at the end of infusion, -32 per cent 150 minutes after the end of infusion). Heart rate and systemic vascular resistance did not vary significantly. Pulmonary vascular resistance increased at the end of infusion, five and ten minutes after the end of infusion (+ 734, +548 and +439 per cent respectively). Plasma volume decreased I0 and 30 minutes after the end of infusion (-28 and -30.5 per cent respectively). per cent at the end of iofusion). Platelet and white cell counts decreased markedly. There was a marked and sustained increase in plasma hista-

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Effets de l'halothane sur les modifications de la PaCO , de l'6quilibre acido-basique et de la ventilation provoqu6es par l"nypoxie chez le rat

The ventilatory effects of prolonged oxygen administration were examined in seven dogs during thiopentone anaesthesia. Ventilation, tidal volume (VT), ventilatory rate (f), minute ventilation (VE), inspiratory time (TI), expiratory time (TE), period (Ttot), TI/Ttot and mean inspiratory flow (VT/TI) were measured during the inhalation of room air, after 30 min of oxygen inhalation, and finally after a return to breathing room air. Arterial blood-gas tensions were measured before and after 5, 10, 20 and 30 min of oxygen administration and 15 min after return to breathing room air. Oxygen administration produced an immediate, significant and persistent decrease in ventilation, principally from a decrease in ventilatory rate and changes in ventilatory times. This was in contrast to what occurred in awake animals. Modifications in ventilatory mechanics or suppression of an hypoxic stimulus to ventilation were probably not involved. Anaesthesia may modify centrally mediated ventilatory responses to hyperoxia.

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