General anaesthetics depress swallowing and this is a reason to delay oral intake after general anaesthesia. The swallowing reflex was studied 2 h after general anaesthesia for patients undergoing colonoscopy. Forty-one patients were anaesthetized with midazolam 75 micrograms.kg-1 followed by a continuous infusion of propofol and 39 patients with propofol 1.5 mg.kg-1 bolus followed by an infusion. Swallowing reflex was measured by electromyography 2 h after induction of anaesthesia, before and 5 min after the administration of flumazenil (0.2 mg) or placebo. Two h after anaesthesia, the state of consciousness was almost normal in all patients and did not change after flumazenil. At two hours, the latency times for the swallowing reflex in patients treated with propofol alone were of 1.4 +/- 0.4 s and were significantly shorter (P < 0.05) than the value of 1.9 +/- 0.8 s observed in patients who received midazolam with propofol. In the latter group the latency time of the swallowing reflex was significantly reduced following the administration of flumazenil but not placebo. In patients who received propofol without midazolam, the administration of flumazenil or placebo was not associated with significant changes in the latency times. There were also no significant differences in the latency times in the subgroup that received midazolam followed by flumazenil and the propofol alone groups that did or did not receive flumazenil. These results suggest that midazolam still exerts a depressive effect on the swallowing reflex 2 h after its administration despite the recovery of normal consciousness.

The swallowing reflex is depressed by anesthetics. During recovery from anesthesia the rapid return of laryngeal and upper airway reflexes is important to protect the lower airway from aspiration. This study measures the recovery of the swallowing reflex after propofol anesthesia. Fifteen patients undergoing a colonoscopy under general anesthesia were studied. No premedication was given. Anesthesia was induced with propofol 2 mg/kg followed by an infusion of 10 mg.kg-1.h-1. The swallowing reflex was measured every 3 min after the end of propofol infusion for 30 min. To initiate swallowing, 0.3 mL of distilled water was injected into the pharynx at two different speeds: a slow injection over 3 s, and a bolus injection. The swallowing reflex was determined by measuring the latency period (i.e., time from water injection to start of electromyographic (EMG) activity measured in the glossal muscles). Swallowing activity was determined by integration of the EMG (EMGi) of the glossal muscles during swallowing. The latency periods after slow and bolus injections were significantly increased for the first 12 min after the end of the propofol infusion and returned to control (preanesthetic values) at 24 min. The EMGi was significantly decreased over the first 12 min and returned to control at 21 min. Propofol depresses the swallowing reflex, but complete recovery is rapid. This study suggests that the oral intake could be allowed early after recovery from anesthesia when propofol is used as the sole anesthetic.

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