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This paper deals with semiqualitative modelling of bioprocesses with a view to their supervision. An analysis of several approaches for modelling shows the difficulties involved in taking into account in a same framework, quantitative and qualitative knowledge, generally available about a process that we want to control. We propose an original approach, placed in the context of semiqualitative modelling, that is supported by a knowledge model the variables and parameters of which are defined by intervals. For these semiqualitative models, we study their properties in simulation and prediction, and more precisely, their fitting based on experimental data. We show that pertinent predictions in a short time can be obtained, making of these semiqualitative models interesting tools for the development of systems for bioprocess supervision.

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